INT264459

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Context Info
Confidence 0.13
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 9
Total Number 9
Disease Relevance 0.95
Pain Relevance 0.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleus (DR1) intracellular (DR1) DNA binding (DR1)
transcription factor binding (DR1)
Anatomy Link Frequency
tear 1
DR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
imagery 5 95.36 Very High Very High Very High
cytokine 48 88.36 High High
Arthritis 24 69.48 Quite High
Inflammation 73 59.88 Quite High
metalloproteinase 112 50.00 Quite Low
agonist 8 50.00 Quite Low
rheumatoid arthritis 40 5.00 Very Low Very Low Very Low
Osteoarthritis 40 5.00 Very Low Very Low Very Low
anesthesia 14 5.00 Very Low Very Low Very Low
Pain 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Dry Eye 19 98.24 Very High Very High Very High
Syndrome 52 97.40 Very High Very High Very High
Disorders Of The Lacrimal System 88 87.64 High High
Chondrosarcoma 48 82.08 Quite High
Arthritis 40 69.48 Quite High
Arthropathy 16 68.28 Quite High
Repression 24 66.64 Quite High
INFLAMMATION 81 59.88 Quite High
Osteoarthritis 40 5.00 Very Low Very Low Very Low
Rheumatoid Arthritis 40 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
at the DR-1/AP-1 site in IL-1?
Gene_expression (site) of DR-1/AP-1
1) Confidence 0.13 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0.07 Pain Relevance 0
and AP-1 transcription factors at the DR-1/AP-1 element, and when considering the competitive binding model, one would expect a decrease in PPAR?
Gene_expression (element) of DR-1/AP-1
2) Confidence 0.13 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0 Pain Relevance 0
at the DR-1/AP-1 site at both promoters in cells treated with IL-1?
Gene_expression (site) of DR-1/AP-1
3) Confidence 0.13 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0 Pain Relevance 0
Although Figure 5 suggests that the putative DR-1 element of the DR-1/AP-1 site does not function as a traditional response element for RXR:PPAR?
Gene_expression (site) of DR-1/AP-1
4) Confidence 0.13 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0 Pain Relevance 0
and AP-1 proteins, altered histone acetylation at the DR-1/AP-1 promoter element, and changes in SUMOylation of PPAR?
Gene_expression (acetylation) of DR-1/AP-1
5) Confidence 0.13 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0.08 Pain Relevance 0.03
Fran├žois and colleagues [17] also identified a similar degenerate DR-1/AP-1 site in the promoters of human MMP-1, MMP-9, and MMP-13, although the function of this site has not been experimentally verified in the human genes.
Gene_expression (site) of DR-1/AP-1
6) Confidence 0.13 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0.32 Pain Relevance 0.13
at the DR-1/AP-1 sites in IL-1?
Gene_expression (sites) of DR-1/AP-1
7) Confidence 0.13 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0.05 Pain Relevance 0
Although Figure 5 suggests that the putative DR-1 element of the DR-1/AP-1 site does not function as a traditional response element for RXR:PPAR?
Gene_expression (site) of DR-1 element
8) Confidence 0.12 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656243 Disease Relevance 0 Pain Relevance 0
DR-1 tear interference camera
Gene_expression (camera) of DR-1 in tear
9) Confidence 0.11 Published 2008 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2698717 Disease Relevance 0.43 Pain Relevance 0.05

General Comments

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