INT26446

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Context Info
Confidence 0.51
First Reported 1989
Last Reported 1993
Negated 0
Speculated 0
Reported most in Abstract
Documents 2
Total Number 3
Disease Relevance 0.23
Pain Relevance 0.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
neuronal 1
portal vein 1
Tns1 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
tetrodotoxin 2 97.22 Very High Very High Very High
Neuropeptide 1 75.00 Quite High
medulla 2 61.04 Quite High
agonist 2 45.68 Quite Low
antagonist 3 32.24 Quite Low
Clonidine 1 25.00 Low Low
guanethidine 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Increased Venous Pressure Under Development 4 81.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Based on experiments on the rat portal vein, it is suggested that NPY is capable of inhibiting TNS-induced release of 3H-NA from the sympathetic nerves via a prejunctional site of action, and that NPY enhances the spontaneous contractility and the vasoconstrictor response to TNS via a postjunctionally mediated mechanism.
Localization (release) of TNS in portal vein
1) Confidence 0.51 Published 1989 Journal Acta Physiol Scand Suppl Section Abstract Doc Link 2557726 Disease Relevance 0 Pain Relevance 0.07
Relaxation was abolished by tetrodotoxin (2 microM) superfused onto and by cold-storage denervation of CA, suggesting that a vasodilating factor (VF) of neuronal origin in CA was released upon TNS.
Localization (released) of TNS in neuronal associated with tetrodotoxin
2) Confidence 0.16 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8474017 Disease Relevance 0.16 Pain Relevance 0.10
Identical frequency-response curves of TNS (2-16 Hz) and concentration-response curves of NO (10-1000 nM) further suggest that < 1000 nM of NO was released from CA upon TNS at the maximal frequency used.
Localization (released) of TNS
3) Confidence 0.14 Published 1993 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 8474017 Disease Relevance 0.07 Pain Relevance 0.06

General Comments

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