INT264478

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Context Info
Confidence 0.02
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 0.12
Pain Relevance 0.17

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (Mapk1, Jun) nucleus (Mapk1, Jun) transcription factor binding (Mapk1, Jun)
nucleoplasm (Mapk1) mitochondrion (Mapk1) aging (Jun)
Anatomy Link Frequency
fibroblasts 1
Mapk1 (Rattus norvegicus)
Jun (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 66 92.64 High High
rheumatoid arthritis 18 73.32 Quite High
Inflammatory stimuli 2 51.20 Quite High
cytokine 11 32.56 Quite Low
Inflammation 13 5.00 Very Low Very Low Very Low
Arthritis 11 5.00 Very Low Very Low Very Low
Potency 6 5.00 Very Low Very Low Very Low
ketamine 1 5.00 Very Low Very Low Very Low
anesthesia 1 5.00 Very Low Very Low Very Low
Inflammatory mediators 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Rheumatoid Arthritis 19 73.32 Quite High
INFLAMMATION 16 50.88 Quite High
Kaposis Sarcoma 1 33.68 Quite Low
Arthritis 8 5.00 Very Low Very Low Very Low
Experimental Arthritis 6 5.00 Very Low Very Low Very Low
Disease 4 5.00 Very Low Very Low Very Low
Cancer 3 5.00 Very Low Very Low Very Low
Necrosis 2 5.00 Very Low Very Low Very Low
Stress 2 5.00 Very Low Very Low Very Low
Pressure And Volume Under Development 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In contrast, the inhibitory effect of PD-98059 showed that AP-1 was activated by ERK1/2 in synovial fibroblasts [39,40] and could contribute to the enhanced production of IL-6 in response to IL-1 [38].
ERK1/2 Positive_regulation (activated) of AP-1 in fibroblasts
1) Confidence 0.02 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656246 Disease Relevance 0.12 Pain Relevance 0.17

General Comments

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