INT26448

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Context Info
Confidence 0.06
First Reported 1989
Last Reported 1989
Negated 0
Speculated 0
Reported most in Abstract
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 0.46

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Npy) signal transduction (Adra2a) extracellular region (Npy)
plasma membrane (Adra2a) cytoplasm (Adra2a) signal transducer activity (Adra2a)
Anatomy Link Frequency
plasma 2
Adra2a (Rattus norvegicus)
Npy (Rattus norvegicus)
Pain Link Frequency Relevance Heat
agonist 2 97.68 Very High Very High Very High
Clonidine 1 97.36 Very High Very High Very High
antagonist 3 95.52 Very High Very High Very High
medulla 2 82.16 Quite High
guanethidine 1 78.88 Quite High
Neuropeptide 1 75.00 Quite High

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Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Based on experiments in the pithed guinea-pig, it is suggested that the PNS-induced increase of the plasma NPY-LI level is modulated by a prejunctional alpha 2-adrenoceptor mediated inhibitory control mechanism, since the alpha 2-agonist clonidine was found to reduce and the alpha 2-antagonist yohimbine to markedly enhance the PNS-induced increase in plasma NPY-LI, whereas the alpha 1-antagonist prazosin had no effect.
2-adrenoceptor Regulation (modulated) of Positive_regulation (increase) of NPY in plasma associated with antagonist, agonist and clonidine
1) Confidence 0.06 Published 1989 Journal Acta Physiol Scand Suppl Section Abstract Doc Link 2557726 Disease Relevance 0 Pain Relevance 0.46

General Comments

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