INT264490

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Context Info
Confidence 0.23
First Reported 2008
Last Reported 2009
Negated 1
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 1.18
Pain Relevance 0.60

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Il6) aging (Il6) extracellular region (Il6)
Il6 (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Inflammation 33 98.52 Very High Very High Very High
agonist 66 94.32 High High
Potency 6 89.52 High High
Arthritis 12 75.12 Quite High
cytokine 12 65.28 Quite High
Inflammatory mediators 3 59.80 Quite High
rheumatoid arthritis 19 59.52 Quite High
Osteoarthritis 21 50.00 Quite Low
anesthesia 1 23.36 Low Low
ketamine 1 22.40 Low Low
Disease Link Frequency Relevance Heat
INFLAMMATION 39 98.52 Very High Very High Very High
Obesity 7 96.08 Very High Very High Very High
Experimental Arthritis 6 75.12 Quite High
Body Weight 12 70.44 Quite High
Necrosis 3 66.28 Quite High
Cancer 4 65.92 Quite High
Arthritis 9 64.60 Quite High
Rheumatoid Arthritis 20 59.52 Quite High
Pressure And Volume Under Development 3 50.76 Quite High
Disease 10 50.48 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
First, we used compounds acting either on RAR or RXR, alone or in combination, to demonstrate that the downregulation of IL-6 was not dependent of RXR activation.
Neg (not) Regulation (dependent) of Negative_regulation (downregulation) of IL-6
1) Confidence 0.23 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656246 Disease Relevance 0.41 Pain Relevance 0.40
PMFs regulated levels of adipocytokines through suppression of TNF-alpha, interferon-gamma, IL-1 beta and IL-6 expression [22].
Regulation (regulated) of Negative_regulation (suppression) of IL-6
2) Confidence 0.03 Published 2009 Journal Nutr J Section Body Doc Link PMC2739863 Disease Relevance 0.77 Pain Relevance 0.20

General Comments

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