INT26451

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Context Info
Confidence 0.75
First Reported 1989
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 14
Total Number 14
Disease Relevance 5.79
Pain Relevance 1.66

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

peptidase activity (KLK1) nucleus (KLK1)
Anatomy Link Frequency
plasma 3
eye 2
nephron 1
TMJ 1
trophoblast cells 1
KLK1 (Homo sapiens)
Pain Link Frequency Relevance Heat
bradykinin 23 100.00 Very High Very High Very High
Inflammation 13 93.68 High High
Snapping jaw 4 92.24 High High
Pain 12 91.60 High High
Dopamine 3 90.60 High High
antagonist 9 88.40 High High
Inflammatory response 1 84.92 Quite High
headache 4 83.84 Quite High
depression 2 26.72 Quite Low
Enkephalin 1 25.00 Low Low
Disease Link Frequency Relevance Heat
Diabetes Mellitus 4 98.12 Very High Very High Very High
Osteoarthritis 3 97.68 Very High Very High Very High
Hypersensitivity 7 97.24 Very High Very High Very High
Hypertension 9 96.88 Very High Very High Very High
Prostate Cancer 67 96.36 Very High Very High Very High
Hereditary Angioedema 50 95.40 Very High Very High Very High
Pressure And Volume Under Development 11 95.12 Very High Very High Very High
Synovitis 1 94.72 High High
Disease 21 93.40 High High
Hemorrhage 1 92.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The authors also hypothesized that cervicovaginal kallikrein expression may result in pathological conditions (e.g.
Gene_expression (expression) of kallikrein
1) Confidence 0.75 Published 2010 Journal Proteome Sci Section Body Doc Link PMC3016264 Disease Relevance 0.14 Pain Relevance 0.03
In this review, evidence is presented that the developing nephron expresses both tissue kallikrein and kininogen, and that the genes encoding the components of the KKS are subject to considerable developmental regulation.
Gene_expression (expresses) of kallikrein in nephron
2) Confidence 0.75 Published 1993 Journal Pediatr. Nephrol. Section Abstract Doc Link 8251340 Disease Relevance 0.26 Pain Relevance 0.22
It is used to inhibit the formation of plasmin and fragments of the Hageman factor, leading to the inhibition of kallikrein and bradykinin production [10].
Gene_expression (production) of kallikrein associated with bradykinin
3) Confidence 0.75 Published 2010 Journal Allergy Asthma Clin Immunol Section Body Doc Link PMC2887436 Disease Relevance 1.04 Pain Relevance 0.12
During the attack, circulating cleaved high-molecular-weight kininogen, kallikrein-alpha 2-macroglobulin complexes, and an altered 50 kd form of kallikrein were detected in the patient's plasma.
Gene_expression (detected) of kallikrein in plasma
4) Confidence 0.75 Published 1994 Journal J. Lab. Clin. Med. Section Abstract Doc Link 8301199 Disease Relevance 0.56 Pain Relevance 0.08
We note that kallikrein levels of these 301 participants are likely to be higher than those of Malmö Preventive Medicine participants not diagnosed with prostate cancer, thus inflating differences between cases and controls in our current analysis.
Gene_expression (levels) of kallikrein associated with prostate cancer
5) Confidence 0.75 Published 2008 Journal BMC Med Section Body Doc Link PMC2275744 Disease Relevance 0.47 Pain Relevance 0
Similar expression patterns of kallikrein, kininogen and kinin receptors indicate that the kallikrein-kinin system may function in an autocrine or paracrine fashion in the eye.
Gene_expression (expression) of kallikrein in eye
6) Confidence 0.75 Published 1996 Journal Exp. Eye Res. Section Abstract Doc Link 8983960 Disease Relevance 0.25 Pain Relevance 0.04
Expression and cellular localization of the kallikrein-kinin system in human ocular tissues.
Gene_expression (Expression) of kallikrein-kinin
7) Confidence 0.68 Published 1996 Journal Exp. Eye Res. Section Title Doc Link 8983960 Disease Relevance 0.49 Pain Relevance 0.16
These results suggest that the tissue kallikrein-kinin system is produced endogenously in human ocular tissues.
Gene_expression (produced) of kallikrein-kinin
8) Confidence 0.68 Published 1996 Journal Exp. Eye Res. Section Abstract Doc Link 8983960 Disease Relevance 0.31 Pain Relevance 0.06
In the present study, we have identified the expression and localization of components of the kallikrein-kinin system in the human eye by reverse transcription-polymerase chain reaction (RT-PCR) and Southern blot analyses, and in situ hybridization histochemistry.
Gene_expression (expression) of kallikrein-kinin in eye
9) Confidence 0.68 Published 1996 Journal Exp. Eye Res. Section Abstract Doc Link 8983960 Disease Relevance 0.56 Pain Relevance 0.17
During the attack, circulating cleaved high-molecular-weight kininogen, kallikrein-alpha 2-macroglobulin complexes, and an altered 50 kd form of kallikrein were detected in the patient's plasma.
Gene_expression (detected) of kallikrein in plasma
10) Confidence 0.65 Published 1994 Journal J. Lab. Clin. Med. Section Abstract Doc Link 8301199 Disease Relevance 0.58 Pain Relevance 0.08
These results clearly demonstrated increased levels of PA, plasmin and kallikrein activities in the synovial fluid of patients with ID and OA, and suggest that these enzymes may be involved in the pathogenesis of synovitis, as well as the resorption of cartilage and bone in TMJ.
Gene_expression (levels) of kallikrein in TMJ associated with snapping jaw, synovitis and osteoarthritis
11) Confidence 0.58 Published 2001 Journal Int J Oral Maxillofac Surg Section Abstract Doc Link 11518356 Disease Relevance 0.68 Pain Relevance 0.33
From these studies reported up to the present, it is suggested that the renal kallikrein-kinin system produced in the distal nephron in the kidney may play a role in the sodium metabolism with other renal depressor systems in addition to its own action.
Gene_expression (produced) of kallikrein-kinin in kidney
12) Confidence 0.29 Published 1989 Journal Adv. Exp. Med. Biol. Section Abstract Doc Link 2557757 Disease Relevance 0 Pain Relevance 0.13
BACKGROUND: Plasma kallikrein plays a major role in the contact (kallikrein-kinin) cascade producing bradykinin.
Gene_expression (producing) of kallikrein-kinin in Plasma associated with bradykinin
13) Confidence 0.16 Published 2008 Journal Expert Opin Biol Ther Section Abstract Doc Link 18613770 Disease Relevance 0.15 Pain Relevance 0.24
Tissue kallikrein protein is present in the same cell types with the exception of trophoblastic cell columns and the various types of extravillous trophoblast cells[120].
Gene_expression (present) of Tissue kallikrein protein in trophoblast cells
14) Confidence 0.05 Published 2009 Journal Reprod Biol Endocrinol Section Body Doc Link PMC2739214 Disease Relevance 0.29 Pain Relevance 0

General Comments

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