INT264523

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Context Info
Confidence 0.03
First Reported 2008
Last Reported 2008
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.24
Pain Relevance 0.30

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (PTGDS, COL2A1) extracellular region (PTGDS, COL2A1) cytoplasm (PTGDS, COL2A1)
isomerase activity (PTGDS) transport (PTGDS) Golgi apparatus (PTGDS)
Anatomy Link Frequency
chondrocytes 2
PTGDS (Homo sapiens)
COL2A1 (Homo sapiens)
Pain Link Frequency Relevance Heat
Inflammation 22 99.80 Very High Very High Very High
Osteoarthritis 47 49.36 Quite Low
metalloproteinase 4 42.32 Quite Low
cytokine 5 18.96 Low Low
Multiple sclerosis 1 6.40 Low Low
COX-2 inhibitor 1 5.00 Very Low Very Low Very Low
Central nervous system 1 5.00 Very Low Very Low Very Low
cINOD 1 5.00 Very Low Very Low Very Low
Inflammatory response 1 5.00 Very Low Very Low Very Low
Pain 1 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
INFLAMMATION 24 99.80 Very High Very High Very High
Apoptosis 3 98.80 Very High Very High Very High
Hypersensitivity 1 97.88 Very High Very High Very High
Targeted Disruption 4 95.40 Very High Very High Very High
Crystal Associated Disease 2 93.16 High High
Atherosclerosis 3 78.04 Quite High
Injury 1 60.44 Quite High
Pleurisy 1 52.68 Quite High
Osteoarthritis 48 50.00 Quite Low
Cancer 1 47.68 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In addition to its anti-inflammatory effects, PGD2 was shown to induce the expression of collagen type II and aggrecan [7], to prevent apoptosis [8], and to inhibit the induction of MMP-1 and MMP-13 [52] in chondrocytes.
PGD2 Positive_regulation (induce) of Gene_expression (expression) of collagen type II in chondrocytes associated with inflammation and apoptosis
1) Confidence 0.03 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656251 Disease Relevance 1.24 Pain Relevance 0.30

General Comments

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