INT264535

Context Info Confidence 0.16 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.39 Pain Relevance 0.22

cell proliferation (TFDP1) nucleoplasm (TFDP1) nucleus (TFDP1) DNA binding (TFDP1) transcription factor binding (TFDP1)

Anatomy Link Frequency chondrocytes 1 TFDP1 (Homo sapiens)

Pain Link Frequency Relevance Heat Osteoarthritis 47 91.92 Inflammation 22 84.24 metalloproteinase 4 50.44 cytokine 5 5.00 COX-2 inhibitor 1 5.00 Central nervous system 1 5.00 cINOD 1 5.00 Inflammatory response 1 5.00 Pain 1 5.00 Multiple sclerosis 1 5.00

Disease Link Frequency Relevance Heat Osteoarthritis 48 91.92 INFLAMMATION 24 84.24 Necrosis 1 48.20 Cancer 1 47.84 Apoptosis 3 23.00 Hypersensitivity 1 16.96 Targeted Disruption 4 14.48 Crystal Associated Disease 2 12.24 Disease 8 5.00 Atherosclerosis 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Indeed, we have recently demonstrated that human chondrocytes express functional DP1 and CRTH-2 and that PGD2 downregulates MMP-1 and MMP-13 expressions through activation of the DP1 pathway [9].

Positive_regulation (activation) of DP1 in chondrocytes

1) Confidence 0.16 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656251 Disease Relevance 0.39 Pain Relevance 0.22

General Comments

This test has worked.