INT264536

Context Info Confidence 0.19 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.56 Pain Relevance 0.26

cell proliferation (TFDP1) nucleoplasm (TFDP1) nucleus (TFDP1) DNA binding (TFDP1) transcription factor binding (TFDP1)

Anatomy Link Frequency chondrocytes 1 TFDP1 (Homo sapiens)

Pain Link Frequency Relevance Heat Osteoarthritis 47 95.88 Inflammation 22 88.20 metalloproteinase 4 54.40 cytokine 5 5.00 COX-2 inhibitor 1 5.00 Central nervous system 1 5.00 cINOD 1 5.00 Inflammatory response 1 5.00 Pain 1 5.00 Multiple sclerosis 1 5.00

Disease Link Frequency Relevance Heat Osteoarthritis 48 95.88 INFLAMMATION 24 88.20 Necrosis 1 52.16 Cancer 1 51.80 Apoptosis 3 26.96 Hypersensitivity 1 20.92 Targeted Disruption 4 18.44 Crystal Associated Disease 2 16.20 Disease 8 5.00 Atherosclerosis 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Indeed, we have recently demonstrated that human chondrocytes express functional DP1 and CRTH-2 and that PGD2 downregulates MMP-1 and MMP-13 expressions through activation of the DP1 pathway [9].

Gene_expression (express) of DP1 in chondrocytes

1) Confidence 0.19 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656251 Disease Relevance 0.56 Pain Relevance 0.26

General Comments

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