INT264548

Context Info Confidence 0.11 First Reported 2008 Last Reported 2008 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.79 Pain Relevance 0.31

peptidase activity (MMP13) extracellular space (MMP13) extracellular region (MMP13) Golgi apparatus (MMP13) proteinaceous extracellular matrix (MMP13) lysosome (MMP13)

Anatomy Link Frequency cartilage 2 MMP13 (Homo sapiens)

Pain Link Frequency Relevance Heat Osteoarthritis 47 89.20 Inflammation 22 80.88 cytokine 5 76.36 metalloproteinase 4 55.52 Inflammatory response 1 42.72 Pain 1 29.92 COX-2 inhibitor 1 5.00 Central nervous system 1 5.00 cINOD 1 5.00 Multiple sclerosis 1 5.00

Disease Link Frequency Relevance Heat Apoptosis 3 97.92 Disease 8 91.04 Osteoarthritis 48 89.20 INFLAMMATION 24 80.88 Targeted Disruption 4 59.20 Crystal Associated Disease 2 38.40 Pressure And Volume Under Development 1 30.76 Pain 1 29.92 Volume Depletion And Dehydration 1 29.76 Arthropathy 1 26.68

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In addition, we have recently shown that PGD2 inhibits the induction of MMP-1 and MMP-13, which play an important role in cartilage damage [9].

Negative_regulation (inhibits) of Positive_regulation (induction) of MMP-13 in cartilage

1) Confidence 0.11 Published 2008 Journal Arthritis Res Ther Section Body Doc Link PMC2656251 Disease Relevance 0.79 Pain Relevance 0.31

General Comments

This test has worked.