INT26459

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.62
First Reported 1985
Last Reported 2011
Negated 6
Speculated 0
Reported most in Abstract
Documents 14
Total Number 14
Disease Relevance 7.27
Pain Relevance 4.92

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (Prl)
Anatomy Link Frequency
uterine 3
uterus 2
body 2
plasma 1
Prl (Mus musculus)
Pain Link Frequency Relevance Heat
Analgesic 4 100.00 Very High Very High Very High
analgesia 1 100.00 Very High Very High Very High
potassium channel 3 99.28 Very High Very High Very High
Multiple sclerosis 121 98.08 Very High Very High Very High
Glutamate 7 97.76 Very High Very High Very High
Dismenorea 43 97.60 Very High Very High Very High
Inflammation 45 96.36 Very High Very High Very High
unmyelinated 1 86.48 High High
Morphine 1 83.36 Quite High
Central nervous system 30 79.20 Quite High
Disease Link Frequency Relevance Heat
Disease 115 98.76 Very High Very High Very High
Galactorrhea 14 98.44 Very High Very High Very High
Cancer 102 98.12 Very High Very High Very High
Multiple Sclerosis 221 98.08 Very High Very High Very High
Dysmenorrhea 43 97.60 Very High Very High Very High
INFLAMMATION 47 96.36 Very High Very High Very High
Adenoma 30 93.28 High High
Sprains And Strains 28 85.48 High High
Hyperplasia 19 83.80 Quite High
Hypopituitarism 1 78.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Long-term exposure to these herbal medicines affected little serum prolactin (PRL) level, estrous cycle, food intake and body growth.
Neg (little) Regulation (affected) of prolactin in body
1) Confidence 0.62 Published 1993 Journal Am. J. Chin. Med. Section Abstract Doc Link 8135171 Disease Relevance 0.49 Pain Relevance 0.33
Long-term exposure to these herbal medicines affected little serum prolactin (PRL) level, estrous cycle, food intake and body growth.
Neg (little) Regulation (affected) of PRL in body
2) Confidence 0.62 Published 1993 Journal Am. J. Chin. Med. Section Abstract Doc Link 8135171 Disease Relevance 0.49 Pain Relevance 0.33
Age-related changes in gonadotropin, prolactin and growth hormone levels with reference to the development of uterine adenomyosis in female SHN mice.
Regulation (changes) of prolactin in uterine associated with dismenorea
3) Confidence 0.59 Published 1993 Journal In Vivo Section Title Doc Link 8364165 Disease Relevance 0.49 Pain Relevance 0.39
Since adenomyosis was induced by chronic hyperprolactinemia, the change of citrate level in the uterus with this lesion might imply some effects of prolactin (PRL) on metabolism and/or secretion of citrate.
Regulation (effects) of prolactin in uterus associated with galactorrhea and dismenorea
4) Confidence 0.45 Published 1996 Journal Life Sci. Section Abstract Doc Link 8594304 Disease Relevance 0.58 Pain Relevance 0.55
Since adenomyosis was induced by chronic hyperprolactinemia, the change of citrate level in the uterus with this lesion might imply some effects of prolactin (PRL) on metabolism and/or secretion of citrate.
Regulation (effects) of PRL in uterus associated with galactorrhea and dismenorea
5) Confidence 0.45 Published 1996 Journal Life Sci. Section Abstract Doc Link 8594304 Disease Relevance 0.58 Pain Relevance 0.55
Prolactin induced analgesia is dependent on ATP sensitive potassium channels.
Regulation (dependent) of Prolactin associated with analgesic, potassium channel and analgesia
6) Confidence 0.45 Published 1995 Journal Clin. Exp. Pharmacol. Physiol. Section Title Doc Link 8542676 Disease Relevance 0 Pain Relevance 0.69
Effects of treatment with prolactin or progesterone on the coincidence of mammary tumors and uterine adenomyosis in young SHN mice.
Regulation (Effects) of prolactin in uterine associated with cancer and dismenorea
7) Confidence 0.45 Published 1987 Journal Lab. Anim. Sci. Section Title Doc Link 2885443 Disease Relevance 0.56 Pain Relevance 0.28
However, in normal mice, no significant change was demonstrated in uterine citrate concentration after short-term experimental modulation of the circulating PRL level.
Regulation (modulation) of PRL in uterine
8) Confidence 0.27 Published 1996 Journal Life Sci. Section Abstract Doc Link 8594304 Disease Relevance 0.53 Pain Relevance 0.53
In contrast, plasma PRL levels and the pattern of estrous cycles were little affected by the treatment.
Neg (little) Regulation (affected) of PRL in plasma
9) Confidence 0.27 Published 1985 Journal Eur J Cancer Clin Oncol Section Abstract Doc Link 3830732 Disease Relevance 0.33 Pain Relevance 0.59
g GHRH (1-40) caused a decrease of GH while PRL concentrations remained unchanged.
Neg (unchanged) Regulation (unchanged) of PRL
10) Confidence 0.19 Published 2007 Journal Pituitary Section Body Doc Link PMC2045692 Disease Relevance 0.58 Pain Relevance 0
g i.v.) caused a 98% inhibition of serum GH but no effect on PRL.
Neg (no) Regulation (effect) of PRL
11) Confidence 0.16 Published 2007 Journal Pituitary Section Body Doc Link PMC2045692 Disease Relevance 0.59 Pain Relevance 0
However, when considering the effect of prolactin treatment in neuroimmunologic diseases such as MS, one must recall that prolactin has pro-inflammatory properties which can exacerbate disease, as has been shown in the MS model, EAE [117].
Regulation (effect) of prolactin associated with multiple sclerosis, inflammation and disease
12) Confidence 0.11 Published 2011 Journal Biol Sex Differ Section Body Doc Link PMC3022636 Disease Relevance 0.86 Pain Relevance 0.36
Nevertheless UAG counteracts the effects of AG on glucose and insulin levels, but not its stimulatory action on GH, PRL, ACTH, and cortisol levels, indicating that UAG has metabolic impact, being able to antagonize the effects of AG on insulin and glucose levels, while it is really inactive from the neuroendocrine point of view [67].
Neg (not) Regulation (action) of PRL
13) Confidence 0.07 Published 2010 Journal International Journal of Peptides Section Body Doc Link PMC2911604 Disease Relevance 0.13 Pain Relevance 0.03
The endocrinological studies demonstrated mild or moderate elevation of PRL basal value and hyper-response of PRL and LH for TRH and LH-RH loading test, which suggested disorder of the hypothalamo-hypophysial system.
Regulation (response) of PRL
14) Confidence 0.04 Published 1989 Journal Rinsho Shinkeigaku Section Abstract Doc Link 2557996 Disease Relevance 1.03 Pain Relevance 0.29

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox