INT264594

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Context Info
Confidence 0.20
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.10
Pain Relevance 0.52

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (CA2) extracellular space (CA2) lyase activity (CA2)
response to stress (CA2) cytoplasm (CA2)
Anatomy Link Frequency
red blood cells 2
CA2 (Homo sapiens)
Pain Link Frequency Relevance Heat
addiction 3 99.92 Very High Very High Very High
ketamine 15 91.64 High High
nMDA receptor 5 88.64 High High
beta blocker 4 84.88 Quite High
Neuronal nitric oxide synthase 1 77.20 Quite High
Glutamate 5 72.16 Quite High
antagonist 10 45.92 Quite Low
Dopamine 20 5.00 Very Low Very Low Very Low
Inflammation 16 5.00 Very Low Very Low Very Low
Inflammatory mediators 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Death 20 99.16 Very High Very High Very High
Neuroblastoma 1 96.00 Very High Very High Very High
Ocular Hypertension 110 88.08 High High
Glaucoma 38 81.88 Quite High
Pheochromocytoma 1 68.60 Quite High
Stress 52 55.32 Quite High
Apoptosis 23 50.40 Quite High
Alzheimer's Dementia 23 50.00 Quite Low
Disease 94 44.48 Quite Low
Increased Venous Pressure Under Development 2 36.08 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Dorzolamide decreases the secretion of aqueous humor in the ciliary processes by inhibition of carbonic anhydrase II, the most active isoenzyme and found primarily in red blood cells.
Negative_regulation (decreases) of carbonic anhydrase II Neg (inhibition) Binding (inhibition) of in red blood cells
1) Confidence 0.20 Published 2008 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2693974 Disease Relevance 0.42 Pain Relevance 0.04
Their argument was strengthened by experiments where Ca2+ dependence of these A?
Negative_regulation (strengthened) of Ca2 Binding (experiments) of associated with addiction
2) Confidence 0.13 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656296 Disease Relevance 0.26 Pain Relevance 0.05
Very high Ca2+ concentrations above 100 µM, however, inhibited binding of the fragments, a process that is probably secondary to unspecific Ca2+ binding and has been observed for other protein interactions including CaM binding to TRPV4 [11].
Negative_regulation (inhibited) of Ca2 Binding (binding) of
3) Confidence 0.10 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2867956 Disease Relevance 0 Pain Relevance 0.04
This Ca2+ loading by the mitochondria beyond its buffering capacity reduces the membrane potential and disrupts electron transport, which results in the increased production of the reactive free radical superoxide anion [O·?
Negative_regulation (reduces) of Ca2 Binding (loading) of
4) Confidence 0.04 Published 2009 Journal Toxicological Sciences Section Body Doc Link PMC2769059 Disease Relevance 0.42 Pain Relevance 0.38

General Comments

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