INT264600

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Context Info
Confidence 0.31
First Reported 2007
Last Reported 2010
Negated 0
Speculated 1
Reported most in Body
Documents 8
Total Number 8
Disease Relevance 2.88
Pain Relevance 2.23

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

protein complex (Syp)
Anatomy Link Frequency
neuronal 2
cerebral hemisphere 2
synapses 2
Syp (Rattus norvegicus)
Pain Link Frequency Relevance Heat
amygdala 736 99.84 Very High Very High Very High
cerebral cortex 7 90.40 High High
ischemia 54 88.64 High High
cytokine 5 85.76 High High
antagonist 30 83.52 Quite High
Eae 1 72.04 Quite High
Thalamus 16 68.00 Quite High
Inflammation 15 42.56 Quite Low
Hippocampus 28 39.44 Quite Low
Inflammatory response 7 27.52 Quite Low
Disease Link Frequency Relevance Heat
Shock 101 97.24 Very High Very High Very High
Stress 2 93.08 High High
Neurodegenerative Disease 4 89.12 High High
Cv Unclassified Under Development 48 88.64 High High
Anxiety Disorder 380 87.68 High High
Repression 1 85.68 High High
Parkinson's Disease 66 75.60 Quite High
Stroke 25 69.80 Quite High
Lewy Body Disease 33 69.68 Quite High
Aids-related Complex 5 67.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In support of this hypothesis, we have shown that intra-MGm/PIN infusion of a MEK inhibitor blocks synaptic plasticity in the LA [43] and, more recently, that intra-MGm/PIN infusion of an antisense oligodeoxynucleotide to EGR-1 impairs the training-induced expression of synapsin and synaptophysin at LA synapses [32].
Negative_regulation (impairs) of Gene_expression (expression) of synaptophysin in synapses associated with amygdala
1) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2888610 Disease Relevance 0.35 Pain Relevance 0.48
In contrast, rats given intra-LA infusion of the NO scavenger c-PTIO exhibit a significant decrease in synapsin and synaptophysin expression in the LA, but no significant impairment in the expression of GluR1.
Negative_regulation (decrease) of Gene_expression (expression) of synaptophysin associated with amygdala
2) Confidence 0.31 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2888610 Disease Relevance 0.22 Pain Relevance 0.51
Post hoc analysis using Duncan's t-tests showed that the Paired group exhibited significantly higher expression of GluR1, synapsin, and synaptophysin relative to the Naïve (p<0.001), Tone Alone (p<0.001), or Immediate Shock groups (p<0.001).
Negative_regulation (exhibited) of Gene_expression (expression) of synaptophysin associated with shock
3) Confidence 0.31 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2888610 Disease Relevance 0.80 Pain Relevance 0.17
0.04, p>0.05; synaptophysin: t(10)?
Negative_regulation (p>0.05) of Gene_expression (0.04) of synaptophysin
4) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2888610 Disease Relevance 0.21 Pain Relevance 0.31
0.82, p>0.05; synaptophysin: t(8)?
Negative_regulation (p>0.05) of Gene_expression (0.82) of synaptophysin
5) Confidence 0.27 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2888610 Disease Relevance 0.08 Pain Relevance 0.31
We analyzed only a small number of rat brains to examine BDNF and synaptophysin expression in the whole cerebral hemisphere.
Spec (examine) Negative_regulation (examine) of Spec (examine) Gene_expression (expression) of synaptophysin in cerebral hemisphere
6) Confidence 0.24 Published 2010 Journal Journal of Korean Medical Science Section Body Doc Link PMC2967002 Disease Relevance 0.18 Pain Relevance 0.14
Indeed, the expression of GAP-43, an intracellular growth protein playing a role in sprouting, neuronal pathfinding and branching [53] and the expression of synaptophysin, an integral membrane protein of synaptic vesicles, widely used as an immunohistological marker for the determination of synaptogenesis [54] were both significantly reduced in 3-AB treated animals as compared to vehicle treated animals.
Negative_regulation (reduced) of Gene_expression (expression) of synaptophysin in neuronal
7) Confidence 0.12 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2779656 Disease Relevance 0.54 Pain Relevance 0.20
-synuclein, as well as the Alzheimer neurofibrillary tangle-associated protein phosphorylated tau, concomitant with decreased expression of the synaptic protein synaptophysin (Griffin et al 2006).
Negative_regulation (decreased) of Gene_expression (expression) of synaptic protein synaptophysin
8) Confidence 0.01 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656298 Disease Relevance 0.50 Pain Relevance 0.11

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