INT264609

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Context Info
Confidence 0.43
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 2.44
Pain Relevance 0.07

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cytosol (GSR) mitochondrion (GSR) small molecule metabolic process (GSR)
oxidoreductase activity (GSR) cytoplasm (GSR)
GSR (Homo sapiens)
Pain Link Frequency Relevance Heat
Spinal cord 30 76.72 Quite High
Inflammation 37 5.00 Very Low Very Low Very Low
Multiple sclerosis 26 5.00 Very Low Very Low Very Low
Central nervous system 10 5.00 Very Low Very Low Very Low
COX2 6 5.00 Very Low Very Low Very Low
cytokine 4 5.00 Very Low Very Low Very Low
dexamethasone 4 5.00 Very Low Very Low Very Low
depression 4 5.00 Very Low Very Low Very Low
agonist 4 5.00 Very Low Very Low Very Low
Demyelination 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Stroke 27 98.84 Very High Very High Very High
Affective Disorder 24 97.68 Very High Very High Very High
Stress 132 95.80 Very High Very High Very High
Multiple Sclerosis 132 95.56 Very High Very High Very High
Disease 24 66.16 Quite High
Injury 21 62.00 Quite High
Paralysis 6 54.36 Quite High
Post-traumatic Stress Disorder 3 53.16 Quite High
Aggression 1 49.20 Quite Low
Manic Depressive Disorder 11 33.80 Quite Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A post-mortem study of bipolar patients showed decreased expression of GR mRNA (Perlman et al 2004; Webster et al 2002) and an exaggerated responses to the dex/CRH test in healthy first degree relatives of mood disorder patients has been found (Lauer et al 1998).
Regulation (responses) of Gene_expression (expression) of GR associated with affective disorder
1) Confidence 0.43 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656301 Disease Relevance 0.35 Pain Relevance 0
The modulation of GR biosynthesis may alter responsiveness to stroke treatment and compromise recovery.



Regulation (modulation) of Gene_expression (biosynthesis) of GR associated with stroke
2) Confidence 0.07 Published 2010 Journal Exp Transl Stroke Med Section Abstract Doc Link PMC2954925 Disease Relevance 0.88 Pain Relevance 0
Analysis of another indicator of HPA axis activity and regulation, glucocorticoid receptor (GR) expression, showed an increase in all groups of animals compared with their controls, 21 days after the onset of experiment (figure 1D; F: 14,74, dF: 7), indicating a normal regulation of the HPA axis.


Regulation (regulation) of Gene_expression (expression) of GR
3) Confidence 0.03 Published 2010 Journal J Neuroinflammation Section Body Doc Link PMC2958904 Disease Relevance 1.21 Pain Relevance 0.07

General Comments

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