INT26462

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Context Info
Confidence 0.78
First Reported 1989
Last Reported 2011
Negated 1
Speculated 4
Reported most in Abstract
Documents 44
Total Number 48
Disease Relevance 19.36
Pain Relevance 7.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

ATPase activity (DNAH8) cytoskeleton (DNAH8) cilium (DNAH8)
cytoplasm (DNAH8)
Anatomy Link Frequency
erythrocyte 3
hippocampus 2
skin 2
epithelial cells 2
plasma 1
DNAH8 (Homo sapiens)
Pain Link Frequency Relevance Heat
Hippocampus 5 99.68 Very High Very High Very High
Paracetamol 12 99.64 Very High Very High Very High
ischemia 128 99.58 Very High Very High Very High
headache 17 98.92 Very High Very High Very High
Chronic pancreatitis 2 98.64 Very High Very High Very High
cytokine 240 98.54 Very High Very High Very High
Nav1.2 1 96.80 Very High Very High Very High
Migraine 90 96.32 Very High Very High Very High
sodium channel 100 96.28 Very High Very High Very High
tetrodotoxin 11 95.92 Very High Very High Very High
Disease Link Frequency Relevance Heat
Obesity 7 99.88 Very High Very High Very High
Inflammatory Bowel Disease 94 99.84 Very High Very High Very High
Ganglion Cysts 116 99.64 Very High Very High Very High
Cv Unclassified Under Development 129 99.58 Very High Very High Very High
Body Weight 4 99.54 Very High Very High Very High
Hypoxia 244 99.40 Very High Very High Very High
Interdigitating Dendritic Cell Sarcoma 4 98.96 Very High Very High Very High
Headache 80 98.92 Very High Very High Very High
Hypertension 64 98.80 Very High Very High Very High
Pancreatitis 2 98.64 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
However, in acinar cells, the distribution of Na+,K+-ATPase was not detected in either the normal pancreas or chronic pancreatitis.
Neg (not) Gene_expression (detected) of ATPase in pancreas associated with chronic pancreatitis
1) Confidence 0.78 Published 1989 Journal Nippon Ika Daigaku Zasshi Section Abstract Doc Link 2558124 Disease Relevance 0.45 Pain Relevance 0.19
Expression of H(+)/K(+)-ATPase was recently shown in cardiac and vascular muscle cells and significant inotropic, chronotropic and vasorelaxant effects of proton pump inhibitors were also previously shown on isolated cardiac and vascular muscles.
Gene_expression (Expression) of ATPase in muscles
2) Confidence 0.77 Published 2008 Journal Pharmacol. Res. Section Abstract Doc Link 18647653 Disease Relevance 0 Pain Relevance 0
Changes in demands for Na+ transport alter expression of the Na+,K+ -ATPase subunit isoforms.
Gene_expression (expression) of ATPase
3) Confidence 0.75 Published 2000 Journal Mol. Cell. Biochem. Section Abstract Doc Link 11055550 Disease Relevance 0 Pain Relevance 0
Low ATP1A1 subunit of the ATPase gene mRNA expression in CP was correlated with headache (P=0.002), acral paraesthesias (P=0.004) and CMS score (P<0.001).
Gene_expression (expression) of ATPase associated with altitude sickness and headache
4) Confidence 0.75 Published 2005 Journal Cephalalgia Section Abstract Doc Link 16305600 Disease Relevance 0.85 Pain Relevance 0.41
Defective OXPHOS may be caused by insufficient fuel supply, by defective electron transport chain enzymes (Complexes I - IV), lack of the electron carrier coenzyme Q10, lack of oxygen due to ischemia or anemia, or excessive membrane leakage, resulting in insufficient mitochondrial inner membrane potential for ATP synthesis by the F0F1-ATPase.
Gene_expression (synthesis) of ATPase associated with anaemia and ischemia
5) Confidence 0.65 Published 2001 Journal Ann. Clin. Lab. Sci. Section Abstract Doc Link 11314862 Disease Relevance 0.88 Pain Relevance 0.31
The human hypothalamus produces an endogenous membrane Na+-K+ ATPase inhibitor, digoxin, which can regulate neuronal transmission.
Gene_expression (produces) of ATPase in neuronal
6) Confidence 0.60 Published 2003 Journal Int. J. Neurosci. Section Abstract Doc Link 12745629 Disease Relevance 0 Pain Relevance 0.22
In addition to BAF57, the ATPase BRG1 and BAF170, other members of the hSWI.SNF complex, are also present in the REST.CoREST repressor complex.
Gene_expression (present) of ATPase
7) Confidence 0.58 Published 2002 Journal J. Biol. Chem. Section Abstract Doc Link 12192000 Disease Relevance 0.25 Pain Relevance 0.14
Na+ -transport modulation induces isoform-specific expression of Na+,K+ -Atpase alpha-subunit isoforms in C2C12 skeletal muscle cell.
Gene_expression (expression) of Atpase in skeletal muscle cell
8) Confidence 0.58 Published 2000 Journal Mol. Cell. Biochem. Section Title Doc Link 11055550 Disease Relevance 0 Pain Relevance 0.06
The effects of acetaminophen (0.3-14.5 microM) on methemoglobin levels, superoxide dismutase and Na(+)-K+ ATPase activities of normal and vitamin E or vitamin C pretreated erythrocytes were investigated.
Gene_expression (activities) of ATPase in erythrocytes associated with paracetamol
9) Confidence 0.50 Published 1995 Journal Biochem. Mol. Biol. Int. Section Abstract Doc Link 7627122 Disease Relevance 0 Pain Relevance 0.50
Vitamin E (1mg/dl of erythrocyte suspension) or vitamin C (1mg/dl of erythrocyte suspension) provided partial protection of hemoglobin, superoxide dismutase and Na(+)-K+ ATPase against acetaminophen action.
Spec (partial) Gene_expression (protection) of ATPase in erythrocyte associated with paracetamol
10) Confidence 0.50 Published 1995 Journal Biochem. Mol. Biol. Int. Section Abstract Doc Link 7627122 Disease Relevance 0 Pain Relevance 0.51
During hypoxia-ischemia, there is a reduced production of ATP, which may lead to a decrease in Na+, K+-ATPase activity (37).
Gene_expression (production) of ATPase associated with hypoxia and ischemia
11) Confidence 0.40 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816844 Disease Relevance 0.97 Pain Relevance 0.23
It has also been known that oxygen-containing free radicals produce permanent inhibition of Na+, K+-ATPase, probably via lipid peroxidation during ischemia (38).
Spec (probably) Gene_expression (produce) of ATPase associated with ischemia
12) Confidence 0.36 Published 2004 Journal Journal of Korean Medical Science Section Body Doc Link PMC2816844 Disease Relevance 0.80 Pain Relevance 0.20
ENaC subunit expression was studied by immunohistochemistry, western blot analysis, and in situ hybridization, and Na+, K+-ATPase isoform expression was studied by immunohistochemistry, western blotting, and northern blot analysis.
Gene_expression (expression) of ATPase
13) Confidence 0.19 Published 2004 Journal J. Pathol. Section Abstract Doc Link 15307141 Disease Relevance 0.86 Pain Relevance 0.09
Decreased expression of apical Na+ channels and basolateral Na+, K+-ATPase in ulcerative colitis.
Gene_expression (expression) of ATPase associated with inflammatory bowel disease
14) Confidence 0.19 Published 2004 Journal J. Pathol. Section Title Doc Link 15307141 Disease Relevance 0.83 Pain Relevance 0.07
Na(+),K(+)-ATPase and Mg(2+)-ATPase activities were determined in the hippocampus of treated Hcy- and saline-treated rats.
Spec (determined) Gene_expression (determined) of ATPase in hippocampus associated with hippocampus
15) Confidence 0.17 Published 2002 Journal Neurochem. Res. Section Abstract Doc Link 12515310 Disease Relevance 0.57 Pain Relevance 0.25
Na(+),K(+)-ATPase and Mg(2+)-ATPase activities were determined in the hippocampus of treated Hcy- and saline-treated rats.
Spec (determined) Gene_expression (determined) of ATPase in hippocampus associated with hippocampus
16) Confidence 0.17 Published 2002 Journal Neurochem. Res. Section Abstract Doc Link 12515310 Disease Relevance 0.57 Pain Relevance 0.25
The levels of expression of Na+, K+-ATPase alpha1- and beta1-isoform proteins were also lower in UC patients than in controls, although there were no differences in Na+, K+-ATPase alpha1- and beta1-isoform mRNA levels between the two groups.
Gene_expression (levels) of ATPase associated with inflammatory bowel disease
17) Confidence 0.17 Published 2004 Journal J. Pathol. Section Abstract Doc Link 15307141 Disease Relevance 0.78 Pain Relevance 0.07
The effect of UC on the expression of apical Na+ channels (ENaC) and basolateral Na+, K+-ATPase, the critical determinants of electrogenic Na+ transport, was therefore investigated in this study.
Gene_expression (expression) of ATPase associated with inflammatory bowel disease
18) Confidence 0.17 Published 2004 Journal J. Pathol. Section Abstract Doc Link 15307141 Disease Relevance 0.77 Pain Relevance 0.08
The levels of expression of Na+, K+-ATPase alpha1- and beta1-isoform proteins were also lower in UC patients than in controls, although there were no differences in Na+, K+-ATPase alpha1- and beta1-isoform mRNA levels between the two groups.
Gene_expression (expression) of ATPase associated with inflammatory bowel disease
19) Confidence 0.15 Published 2004 Journal J. Pathol. Section Abstract Doc Link 15307141 Disease Relevance 0.82 Pain Relevance 0.08
Seeded cells retain expression of the functional markers Na(+)/K(+)-ATPase and zona occludens ZO-1; in addition, constructs demonstrated biomechanical properties similar to those of normal corneas.
Gene_expression (expression) of ATPase in corneas
20) Confidence 0.14 Published 2011 Journal Cardiology Research and Practice Section Body Doc Link PMC3021848 Disease Relevance 0 Pain Relevance 0

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