INT264628

Context Info Confidence 0.26 First Reported 2007 Last Reported 2010 Negated 1 Speculated 0 Reported most in Body Documents 3 Total Number 3 Disease Relevance 1.39 Pain Relevance 0.62

extracellular region (GABBR1) plasma membrane (GABBR1) transcription factor binding (GABBR1) cytoplasm (GABBR1) signal transducer activity (GABBR1)

GABBR1 (Homo sapiens)

Pain Link Frequency Relevance Heat GABA receptor 5 100.00 cannabis 52 98.36 GABAergic 18 91.68 Transcranial magnetic stimulation 36 82.60 gABA 8 54.80 Delta-9-tetrahydrocannabinol 4 54.64 Cannabinoid 9 47.36 Glutamate 2 43.36 Dopamine 3 42.48 Neurotransmitter 1 32.24

Disease Link Frequency Relevance Heat Sleep Disorders 61 98.88 Schizophrenia 106 93.52 Cannabis Dependence 24 78.48 Disease 8 18.04 Drug Dependence 43 5.00 Sleep Initiation And Maintenance Disorders 8 5.00 Pain 4 5.00 Pulmonary Disease 4 5.00 Depression 3 5.00 Congenital Anomalies 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In heterodimeric GABAB receptors, GABABR1 binds the ligand while GABABR2 couples to the G protein and is required for targeting GABABR1 to the membrane (Brauner-Osborne et al., 2007).

Regulation (targeting) of GABABR1

1) Confidence 0.26 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2906217 Disease Relevance 0 Pain Relevance 0

Indiplon is a novel sedative-hypnotic that modulates subunits of the GABA receptor complex in order to induce sedation.

Regulation (modulates) of GABA receptor associated with gaba receptor and sleep disorders

2) Confidence 0.08 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656319 Disease Relevance 0.71 Pain Relevance 0.05

This finding corroborates our view that chronic cannabis use may cause a GABAA-mediated reduction of intracortical inhibition without any influence on GABAB activity.

Neg (without) Regulation (influence) of GABAB associated with cannabis

3) Confidence 0.05 Published 2009 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2806533 Disease Relevance 0.68 Pain Relevance 0.57

General Comments

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