INT264628

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Context Info
Confidence 0.26
First Reported 2007
Last Reported 2010
Negated 1
Speculated 0
Reported most in Body
Documents 3
Total Number 3
Disease Relevance 1.39
Pain Relevance 0.62

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular region (GABBR1) plasma membrane (GABBR1) transcription factor binding (GABBR1)
cytoplasm (GABBR1) signal transducer activity (GABBR1)
GABBR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
GABA receptor 5 100.00 Very High Very High Very High
cannabis 52 98.36 Very High Very High Very High
GABAergic 18 91.68 High High
Transcranial magnetic stimulation 36 82.60 Quite High
gABA 8 54.80 Quite High
Delta-9-tetrahydrocannabinol 4 54.64 Quite High
Cannabinoid 9 47.36 Quite Low
Glutamate 2 43.36 Quite Low
Dopamine 3 42.48 Quite Low
Neurotransmitter 1 32.24 Quite Low
Disease Link Frequency Relevance Heat
Sleep Disorders 61 98.88 Very High Very High Very High
Schizophrenia 106 93.52 High High
Cannabis Dependence 24 78.48 Quite High
Disease 8 18.04 Low Low
Drug Dependence 43 5.00 Very Low Very Low Very Low
Sleep Initiation And Maintenance Disorders 8 5.00 Very Low Very Low Very Low
Pain 4 5.00 Very Low Very Low Very Low
Pulmonary Disease 4 5.00 Very Low Very Low Very Low
Depression 3 5.00 Very Low Very Low Very Low
Congenital Anomalies 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In heterodimeric GABAB receptors, GABABR1 binds the ligand while GABABR2 couples to the G protein and is required for targeting GABABR1 to the membrane (Brauner-Osborne et al., 2007).
Regulation (targeting) of GABABR1
1) Confidence 0.26 Published 2010 Journal Frontiers in Cellular Neuroscience Section Body Doc Link PMC2906217 Disease Relevance 0 Pain Relevance 0
Indiplon is a novel sedative-hypnotic that modulates subunits of the GABA receptor complex in order to induce sedation.
Regulation (modulates) of GABA receptor associated with gaba receptor and sleep disorders
2) Confidence 0.08 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656319 Disease Relevance 0.71 Pain Relevance 0.05
This finding corroborates our view that chronic cannabis use may cause a GABAA-mediated reduction of intracortical inhibition without any influence on GABAB activity.
Neg (without) Regulation (influence) of GABAB associated with cannabis
3) Confidence 0.05 Published 2009 Journal Psychopharmacology (Berl) Section Body Doc Link PMC2806533 Disease Relevance 0.68 Pain Relevance 0.57

General Comments

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