INT264629

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Context Info
Confidence 0.72
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 8
Total Number 14
Disease Relevance 5.70
Pain Relevance 0.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

intracellular (Rac1) enzyme binding (Rac1) GTPase activity (Rac1)
cytoplasm (Rac1) cell proliferation (Rac1) cell motility (Rac1)
Anatomy Link Frequency
neck 1
endothelial cells 1
Rac1 (Mus musculus)
Pain Link Frequency Relevance Heat
headache 27 97.64 Very High Very High Very High
nerve block 2 97.28 Very High Very High Very High
backache 12 97.24 Very High Very High Very High
Pain 42 96.24 Very High Very High Very High
anesthesia 2 95.96 Very High Very High Very High
ischemia 12 94.52 High High
Neurotransmitter 2 46.80 Quite Low
Botox 4 35.12 Quite Low
cINOD 5 31.72 Quite Low
Peripheral nervous system 2 10.00 Low Low
Disease Link Frequency Relevance Heat
Clostridium Infection 18 99.98 Very High Very High Very High
Mevalonate Kinase Deficiency 406 99.92 Very High Very High Very High
Muscle Weakness 4 99.60 Very High Very High Very High
Skin Appendage Disease 18 99.04 Very High Very High Very High
Headache 25 97.64 Very High Very High Very High
Low Back Pain 12 97.24 Very High Very High Very High
Cancer 425 96.80 Very High Very High Very High
Pain 36 94.72 High High
Cv Unclassified Under Development 22 94.52 High High
Sialorrhea 18 93.40 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Generation of pSico-Rac1 lentivirus
Localization (Generation) of pSico-Rac1
1) Confidence 0.72 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0 Pain Relevance 0
In addition, Rac1-deletion in Tie2-Cre mice has implied a role for Rac1 in developmental vasculogenesis, due, possibly, to its deletion both in Tie2-positive endothelial cells and in approximately 80% of hematopoetic cells which are also Tie2-positive [25].
Localization (deletion) of Rac1 in endothelial cells
2) Confidence 0.72 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0.47 Pain Relevance 0.05
Our data indicate that the importance of Rac1 in angiogenic processes is revealed only after ?
Localization (importance) of Rac1
3) Confidence 0.72 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0.27 Pain Relevance 0
In vivo tumorigenesis and endothelial-specific Rac1-deletion
Localization (deletion) of Rac1
4) Confidence 0.72 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0.22 Pain Relevance 0
Rac1 flox/flox and Rac1 flox/flox PDGFB-iCreER mice were implanted subcutaneously with tamoxifen (Rac1 flox/flox and Rac1 flox/flox PDGFB-iCreER) or placebo (Rac1 flox/flox PDGFB-iCreER) 1 mg-slow release pellets in the scruff of the neck.
Localization (release) of Rac1 in neck
5) Confidence 0.68 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2842301 Disease Relevance 0.27 Pain Relevance 0
The effect of GGTI on RhoA and Rac1 localization and activation
Localization (localization) of Rac1
6) Confidence 0.53 Published 2010 Journal J Inherit Metab Dis Section Body Doc Link PMC2946549 Disease Relevance 0.18 Pain Relevance 0
However, with respect to Rac1 localization, MKD cells do not appear to be more sensitive toward inhibition with simvastatin than do control cells.
Localization (localization) of Rac1 associated with mevalonate kinase deficiency
7) Confidence 0.53 Published 2010 Journal J Inherit Metab Dis Section Body Doc Link PMC2946549 Disease Relevance 0.34 Pain Relevance 0
Effect of simvastatin on RhoA and Rac1 localization and activation
Localization (localization) of Rac1
8) Confidence 0.53 Published 2010 Journal J Inherit Metab Dis Section Body Doc Link PMC2946549 Disease Relevance 0.22 Pain Relevance 0
To confirm that the observed effect of simvastatin on RhoA and Rac1 activation was due to a shortage of GGPP, we studied the effect of GGTI, an inhibitor of geranylgeranyl transferase, on localization and activation of RhoA and Rac1 and found that GGTI had a similar effect as simvastatin.
Localization (localization) of Rac1
9) Confidence 0.49 Published 2010 Journal J Inherit Metab Dis Section Body Doc Link PMC2946549 Disease Relevance 0.29 Pain Relevance 0
Using the same approach, i.e., reducing the flux through the pathway by incubating control and MKD cells with simvastatin, an inhibitor of HMG-CoA reductase, we now studied the effect on localization and activation of RhoA and Rac1.
Localization (localization) of Rac1 associated with mevalonate kinase deficiency
10) Confidence 0.49 Published 2010 Journal J Inherit Metab Dis Section Body Doc Link PMC2946549 Disease Relevance 0.65 Pain Relevance 0
Fig. 1Effect of simvastatin on the localization and activation of RhoA (a–e) and Rac1 (f–j).
Localization (localization) of Rac1
11) Confidence 0.43 Published 2010 Journal J Inherit Metab Dis Section Body Doc Link PMC2946549 Disease Relevance 0.78 Pain Relevance 0
Fig. 2Effect of geranylgeranyltransferase inhibitor (GGTI) on the localization and activation of RhoA (a–e) and Rac1 (f–j).
Localization (localization) of Rac1
12) Confidence 0.43 Published 2010 Journal J Inherit Metab Dis Section Body Doc Link PMC2946549 Disease Relevance 0.25 Pain Relevance 0
Topical use of botulinum toxin has been suggested for hyperhidrosis as well (Lim et al 2006).
Localization (use) of botulinum toxin associated with skin appendage disease
13) Confidence 0.04 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656321 Disease Relevance 0.96 Pain Relevance 0.45
The anaerobic bacillus Clostridium botulinum secretes seven known serotypes of botulinum toxin, typed alphabetically A–G.
Localization (secretes) of botulinum toxin associated with clostridium infection
14) Confidence 0.04 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656321 Disease Relevance 0.79 Pain Relevance 0.29

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