INT26464

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.80
First Reported 1986
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 15
Total Number 16
Disease Relevance 4.30
Pain Relevance 1.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

ATPase activity (DNAH8) cytoskeleton (DNAH8) cilium (DNAH8)
cytoplasm (DNAH8)
Anatomy Link Frequency
parietal cells 2
blood 1
erythrocyte 1
pancreas 1
posterior 1
DNAH8 (Homo sapiens)
Pain Link Frequency Relevance Heat
Chronic pancreatitis 8 99.90 Very High Very High Very High
adenocard 4 99.88 Very High Very High Very High
agonist 25 92.40 High High
Pain 5 87.76 High High
ischemia 2 86.76 High High
antagonist 24 83.44 Quite High
tetrodotoxin 1 81.08 Quite High
Potency 1 59.56 Quite High
peptic ulcer disease 3 59.44 Quite High
Calcitonin gene-related peptide 26 50.36 Quite High
Disease Link Frequency Relevance Heat
Pancreatitis 8 99.90 Very High Very High Very High
Malignant Neoplastic Disease 8 99.16 Very High Very High Very High
Gastroesophageal Reflux Disease 52 97.80 Very High Very High Very High
Pancreatic Cancer 8 96.04 Very High Very High Very High
Rhabdomyolysis 8 93.44 High High
Injury 9 88.00 High High
Myalgia 3 87.76 High High
Cv Unclassified Under Development 3 86.76 High High
Acute Renal Failure 1 86.08 High High
Increased Venous Pressure Under Development 24 80.72 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Immunohistochemical localization of Na+, K+-ATPase in human normal and malignant pancreatic tissues.
Localization (localization) of ATPase associated with malignant neoplastic disease
1) Confidence 0.80 Published 1989 Journal Nippon Ika Daigaku Zasshi Section Title Doc Link 2558124 Disease Relevance 0.40 Pain Relevance 0.16
Localization of Na+, K+-ATPase in the human pancreas was investigated immunohistochemically using rabbit antisera against Na+, K+-ATPase of the human kidney.
Localization (Localization) of ATPase in kidney
2) Confidence 0.80 Published 1989 Journal Nippon Ika Daigaku Zasshi Section Abstract Doc Link 2558124 Disease Relevance 0.26 Pain Relevance 0.13
The reaction product existed only on the luminal surfaces of both centroacinar and ductal cells in normal pancreatic tissue, whereas in chronic pancreatitis the localization of Na+, K+-ATPase was found frequently on the luminal surfaces of both centroacinar and ductal cells, and on the basolateral surfaces of some ductal cells.
Localization (localization) of ATPase associated with chronic pancreatitis
3) Confidence 0.75 Published 1989 Journal Nippon Ika Daigaku Zasshi Section Abstract Doc Link 2558124 Disease Relevance 0.41 Pain Relevance 0.18
Clinical perspectives of drugs inhibiting acid secretion--H+K+-ATPase inhibitors.
Localization (secretion--H+K+-) of ATPase
4) Confidence 0.73 Published 1986 Journal Scand. J. Gastroenterol. Suppl. Section Title Doc Link 3029857 Disease Relevance 0.27 Pain Relevance 0.11
These results indicate that Na+,K+-ATPase is immunohistochemically localized on the membranes of centroacinar and ductal cells of the human pancreas, and that the antigenicity of Na+,K+-ATPase in pancreatic carcinoma cells differs from that in normal cells.
Localization (localized) of ATPase in pancreas associated with pancreatic cancer
5) Confidence 0.71 Published 1989 Journal Nippon Ika Daigaku Zasshi Section Abstract Doc Link 2558124 Disease Relevance 0.54 Pain Relevance 0.18
Most studies suggest a cascade of events that include depletion of adenosine triphosphate (ATP), impaired function of the Na+- K+ ATPase system, intracellular excess calcium accumulation, sarcolemma damage, and release of intracellular proteins and other substances into blood.
Localization (release) of ATPase in blood associated with adenocard
6) Confidence 0.68 Published 2009 Journal Phys Sportsmed Section Abstract Doc Link 20048490 Disease Relevance 1.14 Pain Relevance 0.14
Neurogenic stimulation of gastric acid secretion by the Na+, K(+)-ATPase inhibitor ouabain in mouse isolated stomach.
Localization (secretion) of ATPase in stomach
7) Confidence 0.68 Published 1996 Journal Gen. Pharmacol. Section Title Doc Link 8842698 Disease Relevance 0 Pain Relevance 0.08
Various other suspected effects, for which there are isolated indications, e.g., inhibition of thromboxane synthesis, preload reduction, interaction with the transport of adenosine, and normalization of the sarcolemmal Na+, K(+)-ATPase activity, are probably of subordinate importance.
Localization (normalization) of ATPase associated with adenocard
8) Confidence 0.65 Published 1987 Journal Cardiovasc Drugs Ther Section Abstract Doc Link 3154674 Disease Relevance 0.24 Pain Relevance 0.15
In vitro and animal studies have demonstrated that rabeprazole is a more potent inhibitor of H+,K(+)-ATPase and acid secretion than omeprazole, and is a more rapid inhibitor of proton pumps than omeprazole, lansoprazole, or pantoprazole.
Localization (secretion) of ATPase
9) Confidence 0.41 Published 1999 Journal Aliment. Pharmacol. Ther. Section Abstract Doc Link 10491723 Disease Relevance 0.17 Pain Relevance 0.06
Measurement of erythrocyte Na+ K+ ATPase [25]
Localization (Measurement) of ATPase in erythrocyte
10) Confidence 0.05 Published 2007 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2127225 Disease Relevance 0 Pain Relevance 0
Approximately 80% of aqueous humor is secreted by the non pigmented ciliary epithelium through an active metabolic process involving a number of enzymatic systems, the most important of which is Na+/K+ ATPase pump, which secretes Na+ ions into the posterior chamber.
Localization (secretes) of ATPase in posterior
11) Confidence 0.05 Published 2008 Journal Current Neuropharmacology Section Body Doc Link PMC2701282 Disease Relevance 0 Pain Relevance 0
These drugs inhibit the final common pathway to acid secretion, the H+/K+ ATPase located in the secretory canalicular membrane of the gastric parietal cell (Sachs et al 1993).
Localization (secretion) of ATPase in parietal cell
12) Confidence 0.02 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2684091 Disease Relevance 0.58 Pain Relevance 0
These include a type I secretion system ATPase, a pyridine nucleotide-disulfide oxidoreductase family protein, a putative transporter, and type IV secretion system proteins VirB9 and VirB8.
Localization (secretion) of ATPase
13) Confidence 0.01 Published 2006 Journal PLoS Genetics Section Body Doc Link PMC1366493 Disease Relevance 0.08 Pain Relevance 0
These include a type I secretion system ATPase, a pyridine nucleotide-disulfide oxidoreductase family protein, a putative transporter, and type IV secretion system proteins VirB9 and VirB8.
Localization (secretion) of ATPase
14) Confidence 0.01 Published 2006 Journal PLoS Genetics Section Body Doc Link PMC1366493 Disease Relevance 0.07 Pain Relevance 0
Administration of glutamine and phenylalanine stimulates H+/K+ ATPase-mediated acid secretion, presumably by the intracellular exchange of amino acids and through a histamine-independent pathway [36].
Localization (secretion) of ATPase
15) Confidence 0.01 Published 2010 Journal Curr Gastroenterol Rep Section Body Doc Link PMC2974196 Disease Relevance 0.08 Pain Relevance 0.03
CaSR present on parietal cells in intact rat gastric glands [26] and human gastric tissue [31] is activated with the divalent cations Ca2+ and Mg2+, which enhances histamine-induced, H+/K+ ATPase-mediated acid secretion.
Localization (secretion) of ATPase in parietal cells
16) Confidence 0.01 Published 2010 Journal Curr Gastroenterol Rep Section Body Doc Link PMC2974196 Disease Relevance 0.05 Pain Relevance 0.10

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox