INT264669

Context Info Confidence 0.30 First Reported 2007 Last Reported 2010 Negated 0 Speculated 0 Reported most in Body Documents 2 Total Number 2 Disease Relevance 0.60 Pain Relevance 0.20

nucleus (AES)

AES (Homo sapiens)

Pain Link Frequency Relevance Heat Multiple sclerosis 88 73.12 Parenteral administration 2 66.12 imagery 1 63.60 depression 4 5.00 headache 3 5.00 corticosteroid 2 5.00 alcohol 2 5.00 cINOD 2 5.00 Central nervous system 1 5.00 Bioavailability 1 5.00

Disease Link Frequency Relevance Heat Recurrence 20 93.44 Demyelinating Disease 89 73.12 Reprotox - General 1 8 61.36 Phobia 4 51.24 Cognitive Disorder 7 46.64 Hypoactive Sexual Desire Disorder 2 30.88 Lipodystrophy 1 29.68 Gynecomastia 1 28.76 Galactorrhea 1 28.20 Necrosis 1 23.32

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In a study of discontinuation patterns in patients receiving IFN beta, patients who stopped therapy as a result of AEs did so after a median period of 13 months on treatment, whereas those who discontinued as a result of treatment failure (defined as non-reduction in pre-treatment relapse rate and/or sustained increase of Expanded Disability Status Scale score of ?

Positive_regulation (stopped) of Positive_regulation (result) of AEs associated with recurrence

1) Confidence 0.30 Published 2010 Journal Patient Prefer Adherence Section Body Doc Link PMC2819898 Disease Relevance 0.41 Pain Relevance 0.20

This may suggest that the frequency of prolactin-related AEs associated with paliperidone ER therapy is underestimated.

Positive_regulation (underestimated) of Positive_regulation (frequency) of AEs

2) Confidence 0.22 Published 2007 Journal Neuropsychiatric Disease and Treatment Section Body Doc Link PMC2656329 Disease Relevance 0.18 Pain Relevance 0

General Comments

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