INT26468

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Context Info
Confidence 0.37
First Reported 1987
Last Reported 2002
Negated 1
Speculated 0
Reported most in Abstract
Documents 21
Total Number 24
Disease Relevance 3.26
Pain Relevance 9.21

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Ghrh, Gh) extracellular region (Ghrh, Gh) cytosol (Gh)
signal transduction (Gh) mitochondrion (Gh) plasma membrane (Gh)
Anatomy Link Frequency
somatotrophs 4
anterior pituitary 4
molar 2
Ghrh (Rattus norvegicus)
Gh (Mus musculus)
Pain Link Frequency Relevance Heat
Clonidine 22 99.82 Very High Very High Very High
narcan 36 99.72 Very High Very High Very High
antagonist 29 99.60 Very High Very High Very High
Somatostatin 12 99.56 Very High Very High Very High
Sumatriptan 22 99.46 Very High Very High Very High
opioid receptor 4 99.38 Very High Very High Very High
opiate 6 98.60 Very High Very High Very High
tetrodotoxin 15 97.80 Very High Very High Very High
Potency 4 97.70 Very High Very High Very High
Neurotransmitter 6 94.48 High High
Disease Link Frequency Relevance Heat
Obesity 16 99.78 Very High Very High Very High
Cushing's Syndrome /

Hypercortisolism

10 98.92 Very High Very High Very High
Polycystic Ovary Syndrome 11 98.84 Very High Very High Very High
Eating Disorder 1 93.60 High High
Fasciculation 1 93.48 High High
Abdominal Pain 1 92.44 High High
Acromegaly 2 75.00 Quite High
Weight Loss 1 75.00 Quite High
Bronchopulmonary Dysplasia 5 71.44 Quite High
Body Weight 3 68.88 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the contrary, naloxone did not induce significant variations on the fasting GHRH-induced GH release.
GHRH Positive_regulation (induced) of Localization (release) of GH associated with narcan
1) Confidence 0.37 Published 1989 Journal Neuroendocrinology Section Abstract Doc Link 2558324 Disease Relevance 0.33 Pain Relevance 0.46
OBJECTIVE: To investigate the effect of naloxone, an opioid receptor antagonist, on the release of growth hormone (GH) induced by the growth hormone-releasing hormone (GHRH) in normal-weight and obese women with PCOS in relation to feeding.
GHRH Positive_regulation (induced) of Localization (release) of GH associated with antagonist, obesity, narcan, polycystic ovary syndrome and opioid receptor
2) Confidence 0.28 Published 2002 Journal Fertil. Steril. Section Abstract Doc Link 12413983 Disease Relevance 0.27 Pain Relevance 0.22
OBJECTIVE: To investigate the effect of naloxone, an opioid receptor antagonist, on the release of growth hormone (GH) induced by the growth hormone-releasing hormone (GHRH) in normal-weight and obese women with PCOS in relation to feeding.
growth hormone-releasing hormone Positive_regulation (induced) of Localization (release) of GH associated with antagonist, obesity, narcan, polycystic ovary syndrome and opioid receptor
3) Confidence 0.28 Published 2002 Journal Fertil. Steril. Section Abstract Doc Link 12413983 Disease Relevance 0.27 Pain Relevance 0.22
The involvement of tetrodotoxin-sensitive Na+ channels and receptor-operated nonspecific Ca2+ channels, and the effects of short-chain fatty acids, on growth hormone (GH) release induced by GH-releasing hormone (GHRH) were investigated in cultured and freshly isolated caprine anterior pituitary cells.
GHRH Positive_regulation (induced) of Localization (release) of GH in anterior pituitary associated with tetrodotoxin
4) Confidence 0.28 Published 1999 Journal Domest. Anim. Endocrinol. Section Abstract Doc Link 10484133 Disease Relevance 0 Pain Relevance 0.27
From these findings we conclude that tetrodotoxin-sensitive Na+ channels and voltage-dependent L-type Ca2+ channels are involved in the cellular mechanism for GHRH-induced GH release, and that short-chain fatty acids such as propionate and butyrate have a direct action on somatotrophs to reduce basal and GHRH-induced GH release, in caprine somatotrophs.
GHRH Positive_regulation (induced) of Localization (release) of GH in somatotrophs associated with tetrodotoxin
5) Confidence 0.28 Published 1999 Journal Domest. Anim. Endocrinol. Section Abstract Doc Link 10484133 Disease Relevance 0 Pain Relevance 0.31
OBJECTIVE: To investigate the effect of naloxone, an opioid receptor antagonist, on the release of growth hormone (GH) induced by the growth hormone-releasing hormone (GHRH) in normal-weight and obese women with PCOS in relation to feeding.
GHRH Positive_regulation (induced) of Localization (release) of growth hormone associated with antagonist, obesity, narcan, polycystic ovary syndrome and opioid receptor
6) Confidence 0.21 Published 2002 Journal Fertil. Steril. Section Abstract Doc Link 12413983 Disease Relevance 0.27 Pain Relevance 0.22
OBJECTIVE: To investigate the effect of naloxone, an opioid receptor antagonist, on the release of growth hormone (GH) induced by the growth hormone-releasing hormone (GHRH) in normal-weight and obese women with PCOS in relation to feeding.
growth hormone-releasing hormone Positive_regulation (induced) of Localization (release) of growth hormone associated with antagonist, obesity, narcan, polycystic ovary syndrome and opioid receptor
7) Confidence 0.21 Published 2002 Journal Fertil. Steril. Section Abstract Doc Link 12413983 Disease Relevance 0.27 Pain Relevance 0.22
From these findings we conclude that tetrodotoxin-sensitive Na+ channels and voltage-dependent L-type Ca2+ channels are involved in the cellular mechanism for GHRH-induced GH release, and that short-chain fatty acids such as propionate and butyrate have a direct action on somatotrophs to reduce basal and GHRH-induced GH release, in caprine somatotrophs.
GHRH Positive_regulation (induced) of Localization (release) of GH in somatotrophs associated with tetrodotoxin
8) Confidence 0.20 Published 1999 Journal Domest. Anim. Endocrinol. Section Abstract Doc Link 10484133 Disease Relevance 0 Pain Relevance 0.29
The involvement of tetrodotoxin-sensitive Na+ channels and receptor-operated nonspecific Ca2+ channels, and the effects of short-chain fatty acids, on growth hormone (GH) release induced by GH-releasing hormone (GHRH) were investigated in cultured and freshly isolated caprine anterior pituitary cells.
GHRH Positive_regulation (induced) of Localization (release) of growth hormone in anterior pituitary associated with tetrodotoxin
9) Confidence 0.20 Published 1999 Journal Domest. Anim. Endocrinol. Section Abstract Doc Link 10484133 Disease Relevance 0 Pain Relevance 0.27
In 3-d cultured cells in Dulbecco's modified Eagle's medium, an increase in GH release induced by GHRH (10 nmol/l) was moderately, but significantly, reduced by a voltage-sensitive Na+ channel antagonist tetrodotoxin (1 micromol).
GHRH Positive_regulation (induced) of Localization (release) of GH associated with tetrodotoxin and antagonist
10) Confidence 0.20 Published 1999 Journal Domest. Anim. Endocrinol. Section Abstract Doc Link 10484133 Disease Relevance 0 Pain Relevance 0.31
In conclusion, our results clearly show that there is no sex-related difference in the potentiating effect of PD on GHRH-induced GH release, ruling out the suggestion that women have increased cholinergic activity, leading to reduced somatostatinergic tone.
GHRH Neg (no) Positive_regulation (induced) of Localization (release) of GH
11) Confidence 0.20 Published 1993 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 8432781 Disease Relevance 0.19 Pain Relevance 0.09
Naloxone infusion reduced the GHRH-induced GH release in normal women.
GHRH Positive_regulation (induced) of Localization (release) of GH associated with narcan
12) Confidence 0.15 Published 1987 Journal Metab. Clin. Exp. Section Abstract Doc Link 3100909 Disease Relevance 0 Pain Relevance 0.57
In obese subjects, GHRH-induced GH release is significantly increased (known as the "paradoxical response").
GHRH Positive_regulation (induced) of Localization (release) of GH associated with obesity
13) Confidence 0.14 Published 2001 Journal Metab. Clin. Exp. Section Abstract Doc Link 11288030 Disease Relevance 0.77 Pain Relevance 0.38
Moreover, to investigate the specificity of this mechanism, GHRH-induced GH release was tested after inducing hypercortisolism and enhancing alpha 2-adrenergic or muscarinic cholinergic tone, by giving clonidine (CLO) or pyridostigmine (PD), respectively.
GHRH Positive_regulation (induced) of Localization (release) of GH associated with clonidine
14) Confidence 0.13 Published 1995 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 7626468 Disease Relevance 0 Pain Relevance 0.30
Sex-related naloxone influence on growth hormone-releasing hormone-induced growth hormone secretion in normal subjects.
growth hormone-releasing hormone Positive_regulation (induced) of Localization (secretion) of growth hormone associated with narcan
15) Confidence 0.11 Published 1987 Journal Metab. Clin. Exp. Section Title Doc Link 3100909 Disease Relevance 0 Pain Relevance 0.68
In this study we investigated whether SU administration influences GHRH-induced GH secretion in 8 acromegalics, and 6 age-matched normal volunteers, as a control group.
GHRH Positive_regulation (induced) of Localization (secretion) of GH associated with sumatriptan
16) Confidence 0.10 Published 1997 Journal Recenti Prog Med Section Abstract Doc Link 9233053 Disease Relevance 0.07 Pain Relevance 0.77
However, the potentiating effect of these drugs on the GHRH-induced GH secretion was only observed for PRO.
GHRH Positive_regulation (induced) of Localization (secretion) of GH
17) Confidence 0.10 Published 1995 Journal J. Steroid Biochem. Mol. Biol. Section Abstract Doc Link 7626468 Disease Relevance 0 Pain Relevance 0.31
Methoxamine and ISO (10(-6) M) increased basal secretion of GH and both enhanced GHRH-stimulated GH secretion.
GHRH Positive_regulation (stimulated) of Localization (secretion) of GH
18) Confidence 0.08 Published 1994 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 7938032 Disease Relevance 0 Pain Relevance 0.76
Somatostatin (10(-7) M) inhibited GHRH-stimulated GH secretion and GH mRNA accumulation.
GHRH Positive_regulation (stimulated) of Localization (secretion) of GH associated with somatostatin
19) Confidence 0.08 Published 1994 Journal Proc. Soc. Exp. Biol. Med. Section Abstract Doc Link 7938032 Disease Relevance 0 Pain Relevance 0.74
Our study documents that 5-HT1 D receptors do not interfere with GHRH-stimulated GH secretion in acromegalic subjects.
GHRH Positive_regulation (stimulated) of Localization (secretion) of GH
20) Confidence 0.07 Published 1997 Journal Recenti Prog Med Section Abstract Doc Link 9233053 Disease Relevance 0.07 Pain Relevance 0.84

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