INT264683

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Context Info
Confidence 0.29
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 1
Disease Relevance 1.10
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell death (VAPB, ALS2) cytosol (ALS2) small molecule metabolic process (VAPB)
Golgi apparatus (VAPB) endoplasmic reticulum (VAPB) structural molecule activity (VAPB)
Anatomy Link Frequency
Vesicle 1
VAPB (Homo sapiens)
ALS2 (Homo sapiens)
Pain Link Frequency Relevance Heat
Glutamate 4 40.00 Quite Low
Glutamate receptor 2 36.00 Quite Low
nMDA receptor 1 32.72 Quite Low
imagery 17 5.00 Very Low Very Low Very Low
Spinal cord 10 5.00 Very Low Very Low Very Low
medulla 7 5.00 Very Low Very Low Very Low
Transcranial magnetic stimulation 5 5.00 Very Low Very Low Very Low
palliative 3 5.00 Very Low Very Low Very Low
Inflammation 3 5.00 Very Low Very Low Very Low
depression 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Motor Neuron Diseases 190 99.68 Very High Very High Very High
Disease 37 93.36 High High
Neurodegenerative Disease 11 79.04 Quite High
Nicotine Addiction 4 67.96 Quite High
Disorder Of Lipid Metabolism 1 61.52 Quite High
Nerve Degeneration 1 49.32 Quite Low
Injury 2 42.24 Quite Low
Frontotemporal Lobar Degeneration 7 31.40 Quite Low
Dementia 12 28.80 Quite Low
Congenital Anomalies 6 22.36 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Other genes causing familial MND include alsin (ALS2) [83,84], senataxin (ALS4) [85], Vesicle associated membrane protein (VAPB, ALS8) [86], Angiogenin [87,88] and a mutation in the p150 subunit of dynactin (DCTN1) [89,90].
VAPB Binding (associated) of ALS2 in Vesicle associated with motor neuron diseases
1) Confidence 0.29 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2656493 Disease Relevance 1.10 Pain Relevance 0

General Comments

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