INT264685

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Context Info
Confidence 0.61
First Reported 2009
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 7
Disease Relevance 8.80
Pain Relevance 0.31

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell death (TARDBP) mRNA processing (TARDBP) nucleolus (TARDBP)
RNA binding (TARDBP) nucleus (TARDBP) DNA binding (TARDBP)
Anatomy Link Frequency
brain 2
TARDBP (Homo sapiens)
Pain Link Frequency Relevance Heat
Substantia nigra 2 84.64 Quite High
Thalamus 2 83.68 Quite High
Hippocampus 2 83.28 Quite High
Spinal cord 20 64.52 Quite High
imagery 35 5.00 Very Low Very Low Very Low
Inflammation 18 5.00 Very Low Very Low Very Low
medulla 14 5.00 Very Low Very Low Very Low
Glutamate receptor 12 5.00 Very Low Very Low Very Low
Transcranial magnetic stimulation 10 5.00 Very Low Very Low Very Low
Glutamate 9 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Frontotemporal Lobar Degeneration 46 99.40 Very High Very High Very High
Motor Neuron Diseases 380 98.04 Very High Very High Very High
Dementia 164 97.72 Very High Very High Very High
Syndrome 50 95.48 Very High Very High Very High
Spinal Muscular Atrophy 20 94.44 High High
Disease 353 91.56 High High
Creutzfeldt Jakob Disease 8 89.40 High High
Parkinson's Disease 32 81.44 Quite High
Frontotemporal Dementia 1 77.60 Quite High
Neurodegenerative Disease 82 70.76 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
A recent finding is that the TAR DNA binding protein 43 (TDP-43) has been shown to be a major protein constituent in the ubiquitin positive (tau and ?
Gene_expression (constituent) of TDP-43
1) Confidence 0.61 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2656493 Disease Relevance 2.10 Pain Relevance 0.16
A recent finding is that the TAR DNA binding protein 43 (TDP-43) has been shown to be a major protein constituent in the ubiquitin positive (tau and ?
Gene_expression (constituent) of binding protein 43
2) Confidence 0.53 Published 2009 Journal Orphanet J Rare Dis Section Body Doc Link PMC2656493 Disease Relevance 2.11 Pain Relevance 0.16
In line with the reported increased gene expression of TDP-43 in brain tissues [69], elevated 45?
Gene_expression (expression) of TDP-43 in brain
3) Confidence 0.35 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2945639 Disease Relevance 1.05 Pain Relevance 0
With respect to FTLD, cNEUPRO found elevated mean levels of the TAR DNA-binding Protein 43 (TDP-43) and reduced A?
Gene_expression (levels) of TDP-43 associated with frontotemporal lobar degeneration
4) Confidence 0.31 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2945639 Disease Relevance 0.98 Pain Relevance 0
With respect to FTLD, cNEUPRO found elevated mean levels of the TAR DNA-binding Protein 43 (TDP-43) and reduced A?
Gene_expression (levels) of TAR DNA-binding Protein 43 associated with frontotemporal lobar degeneration
5) Confidence 0.31 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2945639 Disease Relevance 0.98 Pain Relevance 0
kDa TDP-43 levels were found in the CSF of 12 patients with FTLD as compared to 13 nondemented controls by western-immunoblot [67].
Gene_expression (levels) of TDP-43 associated with frontotemporal lobar degeneration
6) Confidence 0.27 Published 2010 Journal International Journal of Alzheimer's Disease Section Body Doc Link PMC2945639 Disease Relevance 1.04 Pain Relevance 0
Interestingly, genetic studies have shown that the disruption of p62 (Ramesh Babu et al., 2008), VCP (Watts et al., 2004; Neumann et al., 2007), and 19S particle (Bedford et al., 2008a) in the brain leads to ubiquitylated inclusions of tau, TAR-DNA binding protein (TDP-43), and ?
Gene_expression (inclusions) of TAR-DNA binding protein in brain
7) Confidence 0.08 Published 2010 Journal Frontiers in Molecular Neuroscience Section Body Doc Link PMC2901091 Disease Relevance 0.54 Pain Relevance 0

General Comments

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