INT264701

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Context Info
Confidence 0.42
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 0.73
Pain Relevance 0.18

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Hes1) nucleus (Hes1) intracellular (Hes1)
protein complex assembly (Hes1) DNA binding (Hes1) transcription factor binding (Hes1)
Anatomy Link Frequency
neural 2
Hes1 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 36 96.28 Very High Very High Very High
Central nervous system 3 42.28 Quite Low
ketamine 3 5.00 Very Low Very Low Very Low
anesthesia 3 5.00 Very Low Very Low Very Low
alcohol 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 225 97.32 Very High Very High Very High
Apoptosis 15 55.12 Quite High
Severe Combined Immunodeficiency 3 46.96 Quite Low
Central Nervous System Cancer 3 42.52 Quite Low
Medulloblastoma 21 15.92 Low Low
Neurodegenerative Disease 9 5.00 Very Low Very Low Very Low
Brain Tumor 9 5.00 Very Low Very Low Very Low
Body Weight 9 5.00 Very Low Very Low Very Low
Metastasis 6 5.00 Very Low Very Low Very Low
Lymphatic System Cancer 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Overall, we assessed the levels of persistence of adenovirus expression in infected cells, as the down-regulation of HES1 expression due to miR199b carrying the adenovirus expression, thus following tumor growth over time by BLI see Figure 4G–H, and antibodies staining Figure S4L–M (Hes1, Ki67, Gabra6, Nestin, Math-3, see details in Text S1 information).
Negative_regulation (regulation) of Gene_expression (expression) of HES1 associated with cancer and imagery
1) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2656623 Disease Relevance 0.36 Pain Relevance 0.18
Restored HES1 expression also reversed the effects of miR-199b-5p on cell proliferation (Fig. 3B).
Negative_regulation (reversed) of Gene_expression (expression) of HES1
2) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2656623 Disease Relevance 0.19 Pain Relevance 0
At the same time, the transfection of HES1 cDNA into the 199bSC1 clone decreased induction of pro-neural bHLHs and differentiation markers, and increased levels of proliferation genes (Fig. 3C).
Negative_regulation (decreased) of Gene_expression (transfection) of HES1 cDNA in neural
3) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2656623 Disease Relevance 0.18 Pain Relevance 0

General Comments

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