INT264702

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Context Info
Confidence 0.68
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 8
Disease Relevance 1.39
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Hes1) nucleus (Hes1) intracellular (Hes1)
protein complex assembly (Hes1) DNA binding (Hes1) transcription factor binding (Hes1)
Anatomy Link Frequency
Daoy 4
cerebellar granule cells 2
neural 2
Hes1 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 8 52.64 Quite High
imagery 96 5.00 Very Low Very Low Very Low
ketamine 8 5.00 Very Low Very Low Very Low
anesthesia 8 5.00 Very Low Very Low Very Low
alcohol 8 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 600 87.12 High High
Apoptosis 40 65.48 Quite High
Severe Combined Immunodeficiency 8 57.32 Quite High
Central Nervous System Cancer 8 52.88 Quite High
Medulloblastoma 56 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 24 5.00 Very Low Very Low Very Low
Brain Tumor 24 5.00 Very Low Very Low Very Low
Body Weight 24 5.00 Very Low Very Low Very Low
Metastasis 16 5.00 Very Low Very Low Very Low
Lymphatic System Cancer 16 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Restored HES1 expression also reversed the effects of miR-199b-5p on cell proliferation (Fig. 3B).
Positive_regulation (Restored) of Gene_expression (expression) of HES1
1) Confidence 0.68 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2656623 Disease Relevance 0.19 Pain Relevance 0
At the same time, the transfection of HES1 cDNA into the 199bSC1 clone decreased induction of pro-neural bHLHs and differentiation markers, and increased levels of proliferation genes (Fig. 3C).
Positive_regulation (transfection) of Gene_expression (transfection) of HES1 cDNA in neural
2) Confidence 0.68 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2656623 Disease Relevance 0.18 Pain Relevance 0
When full-length HES1 cDNA was cloned and transfected into the stable Daoy-cell 199bSC1 clone, HES1 expression was restored, as evaluated by immunoblotting (Fig. 3A).
Positive_regulation (transfected) of Gene_expression (transfected) of HES1 cDNA in Daoy
3) Confidence 0.49 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2656623 Disease Relevance 0.39 Pain Relevance 0.03
Furthermore, the transient transfection of HES1 cDNA into the stable 199bSC1 clone led to an increase in the percentage of cells in S phase, and a removal of the block on the G0-G1 phase (Fig. 3D).
Positive_regulation (transfection) of Gene_expression (transfection) of HES1 cDNA
4) Confidence 0.49 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2656623 Disease Relevance 0.06 Pain Relevance 0
Furthermore, the transient transfection of HES1 cDNA into the stable 199bSC1 clone led to an increase in the percentage of cells in S phase, and a removal of the block on the G0-G1 phase (Fig. 3D).
Positive_regulation (increase) of Gene_expression (transfection) of HES1 cDNA
5) Confidence 0.49 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2656623 Disease Relevance 0.06 Pain Relevance 0
The effects of restored expression of HES1 on the SP of the stable 199bSC1 clone were also evaluated.
Positive_regulation (restored) of Gene_expression (expression) of HES1
6) Confidence 0.46 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2656623 Disease Relevance 0.05 Pain Relevance 0
When full-length HES1 cDNA was cloned and transfected into the stable Daoy-cell 199bSC1 clone, HES1 expression was restored, as evaluated by immunoblotting (Fig. 3A).
Positive_regulation (restored) of Gene_expression (expression) of HES1 in Daoy
7) Confidence 0.46 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2656623 Disease Relevance 0.32 Pain Relevance 0
HES1 is a key regulator of cerebellum development, as indicated by recent findings that treatment of cerebellar granule cells with Shh increases the levels of HES1 [20].
Positive_regulation (increases) of Gene_expression (levels) of HES1 in cerebellar granule cells
8) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2656623 Disease Relevance 0.14 Pain Relevance 0

General Comments

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