INT264704

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Context Info
Confidence 0.44
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 5
Disease Relevance 1.03
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Hes1) nucleus (Hes1) intracellular (Hes1)
protein complex assembly (Hes1) DNA binding (Hes1) transcription factor binding (Hes1)
Anatomy Link Frequency
Notch 1
Hes1 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 3 59.40 Quite High
imagery 44 5.00 Very Low Very Low Very Low
ketamine 5 5.00 Very Low Very Low Very Low
anesthesia 5 5.00 Very Low Very Low Very Low
alcohol 3 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 225 93.88 High High
Apoptosis 15 72.24 Quite High
Lung Cancer 6 67.92 Quite High
Severe Combined Immunodeficiency 3 64.08 Quite High
Bladder Cancer 3 62.24 Quite High
Central Nervous System Cancer 3 59.64 Quite High
Hepatocellular Cancer 3 52.24 Quite High
Neurodegenerative Disease 9 33.04 Quite Low
Ataxia 3 13.84 Low Low
Ganglion Cysts 4 12.72 Low Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
To confirm that the cellular phenotype is directly correlated with down-regulation of HES1, we performed in vitro cell-rescue experiments.
Regulation (regulation) of HES1
1) Confidence 0.44 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2656623 Disease Relevance 0.43 Pain Relevance 0.03
Decreases in the expression levels of Pax6, Hes1, nestin, and Sox2 suggest that the immature RPCs had begun undergoing differentiation toward more mature states while co-cultured on the polymer scaffolds.
Regulation (Decreases) of Hes1
2) Confidence 0.28 Published 2008 Journal J Ocul Biol Dis Infor Section Body Doc Link PMC2802414 Disease Relevance 0 Pain Relevance 0
Analysis of RNA synthesis in RPCs using RT-PCR revealed marked down-regulation of Pax6, Hes1, B3-tubulin, DCX and partial down-regulation of nestin and Sox2 (Fig. 4).
Regulation (regulation) of Hes1
3) Confidence 0.28 Published 2008 Journal J Ocul Biol Dis Infor Section Body Doc Link PMC2802414 Disease Relevance 0 Pain Relevance 0
Our in-silico analysis of the mirBase targets database [27] was directed towards identification of miRNAs potentially targeting HES1, an effector of the Notch pathway, a fundamental mechanism in the regulation of MB cell proliferation.
Regulation (targeting) of HES1 in Notch
4) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2656623 Disease Relevance 0.60 Pain Relevance 0
Nonetheless, we did not obtain down-regulation of reporter activity when tested under the same conditions where we obtained effects on HES1 3?
Regulation (effects) of HES1
5) Confidence 0.26 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2656623 Disease Relevance 0 Pain Relevance 0

General Comments

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