INT264706

Context Info Confidence 0.40 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.14 Pain Relevance 0

cell adhesion (Hes1) nucleus (Hes1) intracellular (Hes1) protein complex assembly (Hes1) DNA binding (Hes1) transcription factor binding (Hes1)

Anatomy Link Frequency cerebellar granule cells 1 Hes1 (Mus musculus)

Pain Link Frequency Relevance Heat imagery 12 5.00 Central nervous system 1 5.00 ketamine 1 5.00 anesthesia 1 5.00 alcohol 1 5.00

Disease Link Frequency Relevance Heat Cancer 75 79.72 Medulloblastoma 7 5.00 Apoptosis 5 5.00 Neurodegenerative Disease 3 5.00 Brain Tumor 3 5.00 Body Weight 3 5.00 Metastasis 2 5.00 Lymphatic System Cancer 2 5.00 Glioblastoma 2 5.00 Lung Cancer 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

HES1 is a key regulator of cerebellum development, as indicated by recent findings that treatment of cerebellar granule cells with Shh increases the levels of HES1 [20].

Positive_regulation (increases) of HES1 in cerebellar granule cells

1) Confidence 0.40 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2656623 Disease Relevance 0.14 Pain Relevance 0

General Comments

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