INT264708

Context Info Confidence 0.67 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Abstract Documents 1 Total Number 1 Disease Relevance 0.83 Pain Relevance 0

cell adhesion (Hes1) nucleus (Hes1) intracellular (Hes1) protein complex assembly (Hes1) DNA binding (Hes1) transcription factor binding (Hes1)

Anatomy Link Frequency Notch 1 Hes1 (Mus musculus)

Pain Link Frequency Relevance Heat imagery 12 5.00 Central nervous system 1 5.00 ketamine 1 5.00 anesthesia 1 5.00 alcohol 1 5.00

Disease Link Frequency Relevance Heat Cancer 75 92.96 Medulloblastoma 7 70.84 Metastasis 2 25.00 Infection 1 25.00 Apoptosis 5 5.00 Neurodegenerative Disease 3 5.00 Brain Tumor 3 5.00 Body Weight 3 5.00 Lymphatic System Cancer 2 5.00 Glioblastoma 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In a screening of MB cell lines, the miRNA miR-199b-5p was seen to be a regulator of the Notch pathway through its targeting of the transcription factor HES1.

Transcription (transcription) of HES1 in Notch

1) Confidence 0.67 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2656623 Disease Relevance 0.83 Pain Relevance 0

General Comments

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