INT264717

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.42
First Reported 2008
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 7
Total Number 7
Disease Relevance 0.77
Pain Relevance 0.03

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Hes1) nucleus (Hes1) intracellular (Hes1)
protein complex assembly (Hes1) DNA binding (Hes1) transcription factor binding (Hes1)
Anatomy Link Frequency
Daoy 1
Hes1 (Mus musculus)
Pain Link Frequency Relevance Heat
Central nervous system 6 59.40 Quite High
imagery 76 5.00 Very Low Very Low Very Low
ketamine 7 5.00 Very Low Very Low Very Low
anesthesia 7 5.00 Very Low Very Low Very Low
alcohol 6 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 6 100.00 Very High Very High Very High
Cancer 450 93.88 High High
Apoptosis 30 72.24 Quite High
Severe Combined Immunodeficiency 6 64.08 Quite High
Central Nervous System Cancer 6 59.64 Quite High
Hepatocellular Cancer 6 46.84 Quite Low
Bladder Cancer 6 41.44 Quite Low
Lung Cancer 12 38.48 Quite Low
Medulloblastoma 42 5.00 Very Low Very Low Very Low
Brain Tumor 18 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These effects of miR-199b-5p on HES1 protein expression were not restricted to the stable clones or Daoy cells, as D283MED cells transiently transfected with the expression construct for miR-199b-5p also showed reduced HES1 levels (Text S1, Fig.
Negative_regulation (reduced) of HES1 in Daoy
1) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2656623 Disease Relevance 0.08 Pain Relevance 0
Three clones demonstrated reduced HES1 protein levels, one of which (199bSC1) showed no detectable HES1.
Negative_regulation (reduced) of HES1
2) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2656623 Disease Relevance 0 Pain Relevance 0
Here, HES1 levels were restored, suggesting 2-OM block of HES1 repression by miR-199b-5p, providing further confirmation that miR-199b-5p targets HES1 directly.
Negative_regulation (repression) of HES1 associated with repression
3) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2656623 Disease Relevance 0.10 Pain Relevance 0
We believe these findings to be due to an overall lower efficiency of 199bMC1 for reducing HES1 protein levels.
Negative_regulation (reducing) of HES1
4) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2656623 Disease Relevance 0.06 Pain Relevance 0
Here, HES1 levels were restored, suggesting 2-OM block of HES1 repression by miR-199b-5p, providing further confirmation that miR-199b-5p targets HES1 directly.
Negative_regulation (repression) of HES1 associated with repression
5) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2656623 Disease Relevance 0.10 Pain Relevance 0
To confirm that the cellular phenotype is directly correlated with down-regulation of HES1, we performed in vitro cell-rescue experiments.
Negative_regulation (regulation) of HES1
6) Confidence 0.42 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2656623 Disease Relevance 0.43 Pain Relevance 0.03
Analysis of RNA synthesis in RPCs using RT-PCR revealed marked down-regulation of Pax6, Hes1, B3-tubulin, DCX and partial down-regulation of nestin and Sox2 (Fig. 4).
Negative_regulation (down-regulation) of Hes1
7) Confidence 0.27 Published 2008 Journal J Ocul Biol Dis Infor Section Body Doc Link PMC2802414 Disease Relevance 0 Pain Relevance 0

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox