INT26472

Context Info Confidence 0.62 First Reported 1984 Last Reported 2010 Negated 26 Speculated 17 Reported most in Abstract Documents 191 Total Number 210 Disease Relevance 35.84 Pain Relevance 173.10

signal transduction (Oprm1) plasma membrane (Oprm1) signal transducer activity (Oprm1)

Anatomy Link Frequency spinal cord 8 neurons 7 brain 6 neuronal 4 fundus 4 Oprm1 (Mus musculus) Oprm1 - A118G (2) Oprm1 - C1031G (1)

Pain Link Frequency Relevance Heat opioid receptor 2583 100.00 mu opioid receptor 1650 100.00 Morphine 1423 100.00 Opioid 712 100.00 tolerance 495 100.00 Pain 438 100.00 agonist 361 100.00 Analgesic 310 100.00 narcan 289 100.00 antagonist 227 100.00

Disease Link Frequency Relevance Heat Pain 561 100.00 Ganglion Cysts 37 100.00 Bordatella Infection 8 100.00 Burns 91 99.80 Diabetes Mellitus 46 99.78 Urological Neuroanatomy 183 99.70 Aids-related Complex 3 99.60 INFLAMMATION 84 99.44 Repression 141 99.42 Neuropathic Pain 18 99.30

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Thus, the results of the present study revealed that the effects of these naltrexone pretreatments on ethanol-induced locomotion are similar to the previously described changes on MOR activity.

Regulation (changes) of MOR associated with mu opioid receptor

1) Confidence 0.62 Published 2004 Journal Behav. Brain Res. Section Abstract Doc Link 15219707 Disease Relevance 0 Pain Relevance 0.44

Detection of genetic variation affecting OPRM1 expression or mu opioid receptor function would be an important step towards understanding the origins of inter-individual variation in response to mu opioid receptor ligands and in diseases of substance dependence.

Regulation (affecting) of mu opioid receptor associated with drug dependence, addiction, mu opioid receptor and disease

2) Confidence 0.62 Published 1997 Journal Mol. Psychiatry Section Abstract Doc Link 9399694 Disease Relevance 0.36 Pain Relevance 1.10

In particular, screening of genetically modified mice lacking individual GRKs or beta arrestins for alterations in behavioral and biochemical responses to cocaine and morphine has revealed a functional specificity in dopamine and mu-opioid receptor regulation of locomotion and analgesia.

Regulation (regulation) of mu-opioid receptor associated with dopamine, opioid receptor, analgesia, morphine and cocaine

3) Confidence 0.62 Published 2004 Journal Annu. Rev. Neurosci. Section Abstract Doc Link 15217328 Disease Relevance 0.31 Pain Relevance 0.51

Previous pharmacological data using antagonists with preferential actions at mu-, delta-, and kappa-opioid receptors indicate the importance of the mu-opioid receptor in mediating this effect.

Regulation (importance) of mu-opioid receptor associated with antagonist, kappa opioid receptor and opioid receptor

4) Confidence 0.62 Published 2001 Journal Neuroscience Section Abstract Doc Link 11682161 Disease Relevance 0.44 Pain Relevance 0.68

Previous studies indicate that down-regulation of muOR is more likely with high-efficacy opioid agonists (e.g., etorphine), whereas lower efficacy agonists (e.g., morphine) do not regulate muOR density.

Neg (not) Regulation (regulate) of muOR density associated with mu agonist, agonist, morphine and immobilon

5) Confidence 0.61 Published 2005 Journal Synapse Section Abstract Doc Link 15765525 Disease Relevance 0 Pain Relevance 0.80

Although in vivo heterologous regulation of mu-opioid receptor mRNA by non-opioid compounds has been reported, the failure to observe changes in mu-opioid receptor mRNA levels in vivo after treatment with opioid agonists raised the possibility that in vivo homologous regulation by agonists may not occur.

Regulation (regulation) of mu-opioid receptor mRNA associated with mu agonist, agonist, opioid receptor and opioid

6) Confidence 0.61 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9450614 Disease Relevance 0 Pain Relevance 0.89

Regulation of the mu-opioid receptor gene by opioid analgesic drugs has not been observed in rats and mice following in vivo treatments that produce tolerance.

Regulation (Regulation) of mu-opioid receptor associated with analgesic, tolerance, opioid receptor and opioid

7) Confidence 0.61 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9450614 Disease Relevance 0 Pain Relevance 0.75

Although in vivo heterologous regulation of mu-opioid receptor mRNA by non-opioid compounds has been reported, the failure to observe changes in mu-opioid receptor mRNA levels in vivo after treatment with opioid agonists raised the possibility that in vivo homologous regulation by agonists may not occur.

Regulation (changes) of mu-opioid receptor mRNA associated with mu agonist, agonist, opioid receptor and opioid

8) Confidence 0.61 Published 1997 Journal Eur. J. Pharmacol. Section Abstract Doc Link 9450614 Disease Relevance 0 Pain Relevance 1.02

In a previous study we showed that morphine did not desensitize the cloned mu receptor even though it is a potent and effective agonist at the mu receptor.

Neg (not) Regulation (desensitize) of mu receptor associated with agonist and morphine

9) Confidence 0.61 Published 1998 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 9618424 Disease Relevance 0.06 Pain Relevance 0.65

These results demonstrate a significant difference between mu opioid receptor regulation in B6 and D2 mice, and may underlie well documented strain differences in specific opioid-related behaviors.

Regulation (regulation) of mu opioid receptor associated with mu opioid receptor, sprains and strains and opioid

10) Confidence 0.61 Published 1997 Journal Life Sci. Section Abstract Doc Link 9366513 Disease Relevance 0.55 Pain Relevance 0.50

MOR mRNA levels in the DRG were not affected 7 days after inflammation, whereas chronic morphine administration induced a discrete increase (p < 0.05).

Neg (not) Regulation (affected) of MOR mRNA in DRG associated with inflammation, opioid receptor and morphine

11) Confidence 0.61 Published 2007 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 17468301 Disease Relevance 0.57 Pain Relevance 1.80

However, G((i)alpha2) is not required for agonist-induced mu-opioid receptor density regulation in vivo.

Regulation (regulation) of mu-opioid receptor associated with agonist and opioid receptor

12) Confidence 0.61 Published 2003 Journal Synapse Section Abstract Doc Link 12454948 Disease Relevance 0 Pain Relevance 1.48

Modulation of hypothalamic mu-opioid receptor density by estrogen: a quantitative autoradiographic study of the female C57BL/6J mouse.

Regulation (Modulation) of mu-opioid receptor associated with opioid receptor

13) Confidence 0.61 Published 1993 Journal Brain Res. Bull. Section Title Doc Link 8384520 Disease Relevance 0 Pain Relevance 0.10

We demonstrate for the first time a role of PARP-1 as a transcriptional repressor in MOR gene regulation.

Regulation (regulation) of MOR gene associated with mu opioid receptor

14) Confidence 0.60 Published 2008 Journal J. Cell. Mol. Med. Section Abstract Doc Link 18266974 Disease Relevance 0 Pain Relevance 0.45

Furthermore, the differential regulation of mu-opioid receptor abundance by agonists and antagonists in immunoblotting assays contrasts with changes in [3H] DAMGO binding.

Regulation (regulation) of mu-opioid receptor associated with antagonist, agonist and opioid receptor

15) Confidence 0.59 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15363980 Disease Relevance 0 Pain Relevance 1.00

Delivery of the same daily dose of etorphine or naloxone using intermittent (every 24 h for 7 days) s.c. administration had no effect on immunoreactive mu-opioid receptor, [3H] DAMGO binding or dynamin-2 abundance.

Neg (no) Regulation (effect) of mu-opioid receptor associated with narcan, opioid receptor and immobilon

16) Confidence 0.59 Published 2004 Journal Eur. J. Pharmacol. Section Abstract Doc Link 15363980 Disease Relevance 0 Pain Relevance 1.11

These findings provide in vivo evidence that the muOR is differentially regulated in diverse regions of the CNS.

Regulation (regulated) of muOR

17) Confidence 0.58 Published 2002 Journal J. Neurosci. Section Abstract Doc Link 12451149 Disease Relevance 0.30 Pain Relevance 1.19

We used real-time PCR and [35S]GTPgammaS binding assays to examine the changes of MOR mRNA levels and the capability of the mu-opioid agonist peptide ([D-Ala2,(NMe)Phe4,Gly5-ol]enkephalin (DAMGO) in activating regulatory G-proteins via MORs in forebrain membrane fractions of wild-type (w.t., CB1+/+) and CB1 receptor deficient transgenic mice (knockout, CB1-/-).

Spec (examine) Regulation (changes) of MOR mRNA in forebrain associated with targeted disruption, mu agonist, enkephalin and opioid receptor

18) Confidence 0.58 Published 2008 Journal Neurochem. Int. Section Abstract Doc Link 17698254 Disease Relevance 0.18 Pain Relevance 1.07

These data show that regulation of the MOR uORF is independent of the peptide sequence of the uORF.

Regulation (regulation) of MOR uORF associated with mu opioid receptor

19) Confidence 0.55 Published 2007 Journal Nucleic Acids Research Section Body Doc Link PMC1865057 Disease Relevance 0 Pain Relevance 0.10

We demonstrate novel roles as transcriptional regulators in Oprm1 regulation for hnRNP K and ?

Regulation (regulation) of Oprm1

20) Confidence 0.53 Published 2008 Journal Molecular & Cellular Proteomics : MCP Section Abstract Doc Link PMC2494908 Disease Relevance 0.07 Pain Relevance 0.24

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