INT264729

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Context Info
Confidence 0.05
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.25
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Hes1) nucleus (Hes1) intracellular (Hes1)
protein complex assembly (Hes1) DNA binding (Hes1) transcription factor binding (Hes1)
Mir199b (Mus musculus)
Hes1 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 24 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Repression 2 98.94 Very High Very High Very High
Cancer 150 87.04 High High
Hepatocellular Cancer 2 18.84 Low Low
Bladder Cancer 2 13.44 Low Low
Lung Cancer 4 10.48 Low Low
Medulloblastoma 14 5.00 Very Low Very Low Very Low
Apoptosis 10 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 6 5.00 Very Low Very Low Very Low
Brain Tumor 6 5.00 Very Low Very Low Very Low
Body Weight 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the present study, we have identified a mechanism of HES1 gene regulation via the miRNA miR-199b-5p.
miR-199b Regulation (regulation) of HES1 gene
1) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2656623 Disease Relevance 0.15 Pain Relevance 0
Here, HES1 levels were restored, suggesting 2-OM block of HES1 repression by miR-199b-5p, providing further confirmation that miR-199b-5p targets HES1 directly.
miR-199b Regulation (targets) of HES1 associated with repression
2) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2656623 Disease Relevance 0.10 Pain Relevance 0

General Comments

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