INT264734

Context Info Confidence 0.07 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.10 Pain Relevance 0

cell adhesion (Hes1) nucleus (Hes1) intracellular (Hes1) protein complex assembly (Hes1) DNA binding (Hes1) transcription factor binding (Hes1)

Mir199b (Mus musculus) Hes1 (Mus musculus)

Pain Link Frequency Relevance Heat imagery 12 5.00 Central nervous system 1 5.00 ketamine 1 5.00 anesthesia 1 5.00 alcohol 1 5.00

Disease Link Frequency Relevance Heat Repression 1 100.00 Cancer 75 50.00 Hepatocellular Cancer 1 21.92 Bladder Cancer 1 16.52 Lung Cancer 2 13.56 Medulloblastoma 7 5.00 Apoptosis 5 5.00 Neurodegenerative Disease 3 5.00 Brain Tumor 3 5.00 Body Weight 3 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Here, HES1 levels were restored, suggesting 2-OM block of HES1 repression by miR-199b-5p, providing further confirmation that miR-199b-5p targets HES1 directly.

miR-199b Negative_regulation (block) of Negative_regulation (repression) of HES1 associated with repression

1) Confidence 0.07 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2656623 Disease Relevance 0.10 Pain Relevance 0

General Comments

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