INT264735

Context Info Confidence 0.08 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 2 Disease Relevance 0.93 Pain Relevance 0

cell adhesion (Hes1) nucleus (Hes1) intracellular (Hes1) protein complex assembly (Hes1) DNA binding (Hes1) transcription factor binding (Hes1)

Anatomy Link Frequency Notch 1 Hes1 (Mus musculus) Mir199b (Mus musculus)

Pain Link Frequency Relevance Heat imagery 24 5.00 Central nervous system 2 5.00 ketamine 2 5.00 anesthesia 2 5.00 alcohol 2 5.00

Disease Link Frequency Relevance Heat Cancer 150 96.52 Medulloblastoma 14 74.40 Metastasis 4 25.00 Infection 2 25.00 Apoptosis 10 5.00 Neurodegenerative Disease 6 5.00 Brain Tumor 6 5.00 Body Weight 6 5.00 Lymphatic System Cancer 4 5.00 Glioblastoma 4 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

In a screening of MB cell lines, the miRNA miR-199b-5p was seen to be a regulator of the Notch pathway through its targeting of the transcription factor HES1.

HES1 Binding (targeting) of miR-199b in Notch

1) Confidence 0.08 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2656623 Disease Relevance 0.86 Pain Relevance 0

We report here a novel level of regulation of HES1 expression that is driven by miR-199b-5p, which binds to the HES1 3?

HES1 Binding (binds) of miR-199b

2) Confidence 0.06 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2656623 Disease Relevance 0.07 Pain Relevance 0

General Comments

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