INT264736

Context Info Confidence 0.20 First Reported 2009 Last Reported 2009 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.13 Pain Relevance 0

nucleus (Hes1, Notch2) cell differentiation (Notch2) intracellular (Hes1) protein complex assembly (Hes1) DNA binding (Hes1) cytoplasm (Hes1)

Hes1 (Mus musculus) Notch2 (Mus musculus)

Pain Link Frequency Relevance Heat imagery 12 5.00 Central nervous system 1 5.00 ketamine 1 5.00 anesthesia 1 5.00 alcohol 1 5.00

Disease Link Frequency Relevance Heat Cancer 75 77.56 Medulloblastoma 7 5.00 Apoptosis 5 5.00 Neurodegenerative Disease 3 5.00 Brain Tumor 3 5.00 Body Weight 3 5.00 Metastasis 2 5.00 Lymphatic System Cancer 2 5.00 Glioblastoma 2 5.00 Lung Cancer 2 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

This suggests that HES1 is a transcriptional target of both the Shh and Notch2 signaling cascades.

HES1 Regulation (target) of Notch2

1) Confidence 0.20 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2656623 Disease Relevance 0.13 Pain Relevance 0

General Comments

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