INT264738

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Context Info
Confidence 0.08
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.89
Pain Relevance 0

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell adhesion (Hes1) nucleus (Hes1) intracellular (Hes1)
protein complex assembly (Hes1) DNA binding (Hes1) transcription factor binding (Hes1)
Anatomy Link Frequency
Daoy 2
Mir199b (Mus musculus)
Hes1 (Mus musculus)
Pain Link Frequency Relevance Heat
imagery 24 5.00 Very Low Very Low Very Low
Central nervous system 2 5.00 Very Low Very Low Very Low
ketamine 2 5.00 Very Low Very Low Very Low
anesthesia 2 5.00 Very Low Very Low Very Low
alcohol 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Cancer 150 91.68 High High
Medulloblastoma 14 69.56 Quite High
Repression 2 67.12 Quite High
Hepatocellular Cancer 2 39.76 Quite Low
Bladder Cancer 2 34.36 Quite Low
Lung Cancer 4 31.40 Quite Low
Metastasis 4 25.00 Low Low
Infection 2 25.00 Low Low
Apoptosis 10 5.00 Very Low Very Low Very Low
Neurodegenerative Disease 6 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Down-regulation of HES1 expression by miR-199b-5p negatively regulates the proliferation rate and anchorage-independent growth of MB cells.
miR-199b Regulation (regulation) of Gene_expression (expression) of HES1
1) Confidence 0.08 Published 2009 Journal PLoS ONE Section Abstract Doc Link PMC2656623 Disease Relevance 0.82 Pain Relevance 0
These effects of miR-199b-5p on HES1 protein expression were not restricted to the stable clones or Daoy cells, as D283MED cells transiently transfected with the expression construct for miR-199b-5p also showed reduced HES1 levels (Text S1, Fig.
miR-199b Regulation (effects) of Gene_expression (expression) of HES1 in Daoy
2) Confidence 0.05 Published 2009 Journal PLoS ONE Section Body Doc Link PMC2656623 Disease Relevance 0.07 Pain Relevance 0

General Comments

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