INT26477

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Context Info
Confidence 0.45
First Reported 1987
Last Reported 2010
Negated 3
Speculated 4
Reported most in Body
Documents 26
Total Number 29
Disease Relevance 16.31
Pain Relevance 4.33

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

endosome (ACE) peptidase activity (ACE) extracellular space (ACE)
extracellular region (ACE) plasma membrane (ACE)
Anatomy Link Frequency
platelets 2
blood 1
plaques 1
endothelium 1
skin 1
ACE (Homo sapiens)
Pain Link Frequency Relevance Heat
beta blocker 40 100.00 Very High Very High Very High
Inflammation 25 100.00 Very High Very High Very High
agonist 4 100.00 Very High Very High Very High
cINOD 2 100.00 Very High Very High Very High
Calcium channel 6 99.92 Very High Very High Very High
Opioid 3 99.00 Very High Very High Very High
fluoxetine 7 98.80 Very High Very High Very High
Migraine 4 98.12 Very High Very High Very High
Angina 6 97.64 Very High Very High Very High
alcohol 14 97.56 Very High Very High Very High
Disease Link Frequency Relevance Heat
INFLAMMATION 33 100.00 Very High Very High Very High
Disorder Of Lipid Metabolism 6 100.00 Very High Very High Very High
Hypertension 177 99.92 Very High Very High Very High
Proteinuria 91 99.80 Very High Very High Very High
Left Ventricular Hypertrophy 4 99.48 Very High Very High Very High
Glaucoma 80 99.40 Very High Very High Very High
Diabetes Mellitus 74 99.26 Very High Very High Very High
Atherosclerosis 119 99.24 Very High Very High Very High
Hypotension 17 99.24 Very High Very High Very High
Diabetic Retinopathy 36 98.92 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The effects of dietary protein, nonsteroidal anti-inflammatory drugs, and angiotensin-converting enzyme inhibitors on nephrotic proteinuria and their potential hormonal mechanisms of action is the subject of this review.
Regulation (effects) of angiotensin-converting enzyme associated with inflammation, proteinuria and cinod
1) Confidence 0.45 Published 1993 Journal Am. J. Nephrol. Section Abstract Doc Link 8116686 Disease Relevance 1.32 Pain Relevance 0.19
Effects of an alpha-2 adrenoceptor agonist on angiotensin converting enzyme inhibitor-induced hypotension and potentiated allergen-evoked inflammatory skin responses.
Regulation (Effects) of angiotensin converting enzyme in skin associated with inflammation, hypotension and agonist
2) Confidence 0.45 Published 1988 Journal J. Pharmacol. Exp. Ther. Section Title Doc Link 2898524 Disease Relevance 0.69 Pain Relevance 0.51
Feringa et al (2006) sought to determine the effect of chronic treatment with cardiac medication, including statins, beta-blockers, aspirins, ACE-I, calcium channel blockers, diuretics, nitrates, coumarins, and digoxin on long-term mortality among patients with PAD (Feringa et al 2006).
Spec (determine) Regulation (effect) of ACE-I associated with beta blocker, calcium channel and peripheral arterial disease
3) Confidence 0.44 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663435 Disease Relevance 1.27 Pain Relevance 0.19
The Trial on Reversing Endothelial Dysfunction (TREND) showed convincing evidence for an effect of ACE inhibition on the endothelium-dependent vasodilation in subjects with coronary heart disease (Mancini et al 1996).
Regulation (effect) of ACE in endothelium associated with coronary artery disease and increased venous pressure under development
4) Confidence 0.44 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2663435 Disease Relevance 1.33 Pain Relevance 0
Further research will clarify the role of bronchodilators and angiotensin-converting enzyme inhibitors in the prehospital setting.
Regulation (role) of angiotensin-converting enzyme
5) Confidence 0.44 Published 2009 Journal Heart failure clinics Section Abstract Doc Link 19026382 Disease Relevance 0.16 Pain Relevance 0.09
Extra-familial ACE
Regulation (familial) of ACE
6) Confidence 0.44 Published 2007 Journal Biopsychosoc Med Section Body Doc Link PMC1852322 Disease Relevance 0.24 Pain Relevance 0.05
Whether their outcome would have been improved if their proteinuria had been controlled with ACEI/ARB therapy is the subject of current investigation.
Regulation (controlled) of ACEI associated with proteinuria
7) Confidence 0.44 Published 2008 Journal Biologics : Targets & Therapy Section Body Doc Link PMC2727881 Disease Relevance 1.36 Pain Relevance 0.09
The effects of the apolipoprotein E epsilon and angiotensin-converting enzyme insertion/deletion alleles on lipid levels and hypolipidemic drug treatment was assessed in 400 men with stable angina pectoris or healed myocardial infarction and 338 healthy controls.
Regulation (effects) of angiotensin-converting enzyme associated with stable angina pectoris, angina, myocardial infarction and disorder of lipid metabolism
8) Confidence 0.44 Published 2003 Journal Am. J. Cardiol. Section Abstract Doc Link 14583365 Disease Relevance 0.52 Pain Relevance 0.17
Clinical data exists that indicates an effect of ACE inhibitors in the prevention of myocardial infarction and unstable angina [10,14].
Regulation (effect) of ACE associated with angina and myocardial infarction
9) Confidence 0.44 Published 2001 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC59642 Disease Relevance 1.41 Pain Relevance 0.10
The importance of ACE inhibitors in the progression of coronary disease has also been demonstrated in clinical studies.
Regulation (importance) of ACE associated with coronary heart disease
10) Confidence 0.44 Published 2001 Journal Curr Control Trials Cardiovasc Med Section Body Doc Link PMC59642 Disease Relevance 1.35 Pain Relevance 0.14
Date of diagnosis significantly affected baseline ACE levels (Figure 2d).
Regulation (affected) of ACE
11) Confidence 0.41 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945057 Disease Relevance 0.08 Pain Relevance 0
Although this covariate significantly affected only baseline ACE levels (see Figure 2d), it had no influence on the other biomarkers, for example, platelets and ferritin.
Regulation (affected) of ACE in platelets
12) Confidence 0.41 Published 2010 Journal Arthritis Res Ther Section Body Doc Link PMC2945057 Disease Relevance 0.33 Pain Relevance 0.12
ACE inhibitor therapy in combination with a diuretic has been shown to be effective in reducing left ventricular hypertrophy (LVH) (Mancia et al 1997).
Regulation (effective) of ACE associated with left ventricular hypertrophy
13) Confidence 0.39 Published 2006 Journal Vascular Health and Risk Management Section Body Doc Link PMC1994025 Disease Relevance 0.62 Pain Relevance 0
There are no formal studies on the effects of angiotensin converting enzyme inhibitors and vasodilators on sleep in man.
Regulation (effects) of angiotensin converting enzyme
14) Confidence 0.39 Published 1987 Journal Life Sci. Section Abstract Doc Link 2890073 Disease Relevance 0 Pain Relevance 0.28
For example, it is likely that antiatherosclerotic effects depend on perindopril’s affinity for tissue ACE in the endothelium and lipophilicity allowing penetration of atherosclerotic plaques.
Spec (likely) Regulation (depend) of ACE in plaques associated with atherosclerotic plaque
15) Confidence 0.38 Published 2007 Journal Core Evidence Section Body Doc Link PMC3012553 Disease Relevance 0.23 Pain Relevance 0
The results of both the EUCLID and normotensive ABCD studies show significant beneficial effects of ACE inhibition on progress of diabetic retinopathy in diabetic patients in the absence of hypertension, but the mechanisms that contribute to this response have yet to be identified.
Regulation (effects) of ACE associated with diabetes mellitus, hypertension and diabetic retinopathy
16) Confidence 0.33 Published 2007 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2701139 Disease Relevance 1.20 Pain Relevance 0.06
Randomized, controlled clinical trials have not been performed to clarify neuroprotective effects of ACE inhibitors in glaucoma yet.
Regulation (effects) of ACE associated with glaucoma
17) Confidence 0.33 Published 2007 Journal Clinical ophthalmology (Auckland, N.Z.) Section Body Doc Link PMC2701139 Disease Relevance 0.96 Pain Relevance 0
A safer way of producing therapeutic effects is promised by the delivery of the ACE antisense sequences by a vector producing a permanent inhibition of ACE and long-term control of blood pressure in hypertensive patients.
Regulation (control) of ACE in blood associated with hypertension
18) Confidence 0.27 Published 2003 Journal Curr. Pharm. Des. Section Abstract Doc Link 12570787 Disease Relevance 0.67 Pain Relevance 0.17
OBJECTIVE: To evaluate the literature examining the efficacy of angiotensin-converting enzyme (ACE) inhibitors and angiotensin receptor blockers (ARBs) for migraine prophylaxis.
Spec (examining) Regulation (efficacy) of ACE associated with migraine
19) Confidence 0.27 Published 2010 Journal Ann Pharmacother Section Abstract Doc Link 20086184 Disease Relevance 0.17 Pain Relevance 0.10
There was no significant difference regarding ACE levels in patients with metastasis and without metastasis.
Neg (no) Regulation (regarding) of ACE
20) Confidence 0.27 Published 2008 Journal Hepatogastroenterology Section Body Doc Link 19102399 Disease Relevance 0.07 Pain Relevance 0

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