INT264775

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Context Info
Confidence 0.03
First Reported 2007
Last Reported 2007
Negated 0
Speculated 2
Reported most in Body
Documents 1
Total Number 4
Disease Relevance 0
Pain Relevance 0.64

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

mitochondrion (Abat) signal transduction (Gabbr1) plasma membrane (Gabbr1)
transcription factor binding (Gabbr1) cytoplasm (Gabbr1) signal transducer activity (Gabbr1)
Gabbr1 (Mus musculus)
Abat (Rattus norvegicus)
Pain Link Frequency Relevance Heat
gABA 80 100.00 Very High Very High Very High
antagonist 40 97.48 Very High Very High Very High
agonist 180 96.36 Very High Very High Very High
Potency 40 62.32 Quite High
cocaine 28 5.00 Very Low Very Low Very Low
addiction 28 5.00 Very Low Very Low Very Low
alcohol 24 5.00 Very Low Very Low Very Low
Neurotransmitter 16 5.00 Very Low Very Low Very Low
tolerance 16 5.00 Very Low Very Low Very Low
GABAergic 16 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Anxiety Disorder 52 5.00 Very Low Very Low Very Low
Drug Dependence 20 5.00 Very Low Very Low Very Low
Cognitive Disorder 12 5.00 Very Low Very Low Very Low
Demyelinating Disease 8 5.00 Very Low Very Low Very Low
Sleep Disorders 8 5.00 Very Low Very Low Very Low
Spasticity 8 5.00 Very Low Very Low Very Low
Absence Epilepsy 4 5.00 Very Low Very Low Very Low
Depression 4 5.00 Very Low Very Low Very Low
Stress 4 5.00 Very Low Very Low Very Low
INFLAMMATION 4 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although GABA binds in the GABAB1 VFT, it is now well demonstrated that the GABAB2 HD is responsible for G-protein activation (Fig. 1).
GABAB1 Binding (binds) of GABA associated with gaba
1) Confidence 0.03 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2656813 Disease Relevance 0 Pain Relevance 0.18
In summary, the GABAB receptor is a complex allosteric protein made or four main domains working "de concert" to allow GABA binding in the VFT of one subunit (GABAB1) to activate the HD of the associated subunit (GABAB2), likely through relative movement between these domains (Fig. 1).
GABAB1 Spec (likely) Binding (binding) of GABA associated with gaba
2) Confidence 0.03 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2656813 Disease Relevance 0 Pain Relevance 0.13
In the case of the GABAB receptor, GABA and all other orthosteric ligands bind to the GABAB1 VFT only, notably by interacting with Ser246 and Glu465 (nomenclature based on the rat GABAB1a sequence) [24, 39, 52].
GABAB1 Binding (bind) of GABA associated with gaba
3) Confidence 0.02 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2656813 Disease Relevance 0 Pain Relevance 0.19
In summary, the GABAB receptor is a complex allosteric protein made or four main domains working "de concert" to allow GABA binding in the VFT of one subunit (GABAB1) to activate the HD of the associated subunit (GABAB2), likely through relative movement between these domains (Fig. 1).
GABAB2 Spec (likely) Binding (binding) of GABA associated with gaba
4) Confidence 0.02 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2656813 Disease Relevance 0 Pain Relevance 0.14

General Comments

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