INT264782

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Context Info
Confidence 0.02
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.06
Pain Relevance 0.28

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CRH) extracellular space (CRH) extracellular region (CRH)
plasma membrane (CRHR1) signal transducer activity (CRHR1) response to stress (CRH)
CRH (Homo sapiens)
CRHR1 (Homo sapiens)
Pain Link Frequency Relevance Heat
antagonist 60 96.76 Very High Very High Very High
agonist 28 75.80 Quite High
Migraine 2 39.16 Quite Low
depression 4 5.00 Very Low Very Low Very Low
spastic colon 2 5.00 Very Low Very Low Very Low
Potency 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Hypercalcemia 2 63.60 Quite High
Headache 2 39.16 Quite Low
Hyperglycemia 4 36.24 Quite Low
Traumatic Stress Disorders 2 34.24 Quite Low
Disease 4 9.24 Low Low
Stress 10 5.00 Very Low Very Low Very Low
Diabetes Mellitus 4 5.00 Very Low Very Low Very Low
Anxiety Disorder 4 5.00 Very Low Very Low Very Low
Depression 4 5.00 Very Low Very Low Very Low
Functional Bowel Disorder 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The use of [125I]CRF enabled detection of the initial lead compounds because this radioligand binds strongly to the J-domain of the CRF1 receptor [38].
CRF Binding (binds) of CRF1 receptor
1) Confidence 0.02 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2656815 Disease Relevance 0.06 Pain Relevance 0.06
Binding of a radiolabeled amino-terminal-truncated peptide ([125I] astressin, a CRF(12-41) analogue) to the wild-type CRF1 receptor is not appreciably inhibited by nonpeptide ligands [37, 38, 64], and nonpeptide antagonists completely block CRF-stimulated activation of a J-domain fragment [38, 59].
CRF Binding (Binding) of CRF1 receptor associated with antagonist
2) Confidence 0.02 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2656815 Disease Relevance 0 Pain Relevance 0.21

General Comments

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