INT264800

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Context Info
Confidence 0.07
First Reported 2007
Last Reported 2007
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.17
Pain Relevance 0.59

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

small molecule metabolic process (GLP1R) plasma membrane (GLP1R) signal transducer activity (GLP1R)
GLP1R (Homo sapiens)
Pain Link Frequency Relevance Heat
Potency 2 98.28 Very High Very High Very High
agonist 28 95.08 Very High Very High Very High
antagonist 60 89.04 High High
depression 4 5.00 Very Low Very Low Very Low
Migraine 2 5.00 Very Low Very Low Very Low
spastic colon 2 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Targeted Disruption 2 98.60 Very High Very High Very High
Diabetes Mellitus 4 44.64 Quite Low
Hyperglycemia 4 43.20 Quite Low
Stress 10 5.00 Very Low Very Low Very Low
Anxiety Disorder 4 5.00 Very Low Very Low Very Low
Disease 4 5.00 Very Low Very Low Very Low
Depression 4 5.00 Very Low Very Low Very Low
Functional Bowel Disorder 2 5.00 Very Low Very Low Very Low
Hypercalcemia 2 5.00 Very Low Very Low Very Low
Headache 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Although the modulator enhances the binding of GLP-1 it does not detectably enhance the signaling activity of the peptide.


Positive_regulation (enhances) of GLP-1 Binding (binding) of
1) Confidence 0.07 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2656815 Disease Relevance 0.10 Pain Relevance 0.30
This nonpeptide ligand enhances the binding of [125I]GLP-1 to the GLP-1 receptor and directly activates the receptor, with potency of approximately 100nM.
Positive_regulation (enhances) of GLP-1 receptor Binding (binding) of associated with potency
2) Confidence 0.04 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2656815 Disease Relevance 0.07 Pain Relevance 0.29

General Comments

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