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Context Info
Confidence 0.08
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 2
Total Number 2
Disease Relevance 0.19
Pain Relevance 0.40

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

nucleoplasm (Ppp1ca) nucleus (Ppp1ca) cell cycle (Ppp1ca)
carbohydrate metabolic process (Ppp1ca) cell division (Ppp1ca) cytoplasm (Ppp1ca)
Ppp1ca (Mus musculus)
Pain Link Frequency Relevance Heat
Nucleus accumbens 19 87.92 High High
Dopamine 23 87.56 High High
amygdala 4 81.44 Quite High
Hippocampus 9 77.76 Quite High
addiction 35 66.76 Quite High
antagonist 2 56.28 Quite High
Thalamus 2 38.24 Quite Low
cocaine 11 35.04 Quite Low
cerebral cortex 2 21.12 Low Low
Pyramidal cell 1 8.64 Low Low
Disease Link Frequency Relevance Heat
Targeted Disruption 24 64.80 Quite High
Anxiety Disorder 2 56.48 Quite High
Apoptosis 4 47.04 Quite Low
Frailty 2 30.48 Quite Low
Stress 1 16.28 Low Low
Drug Dependence 7 5.00 Very Low Very Low Very Low
Cold Sores 7 5.00 Very Low Very Low Very Low
Recurrence 4 5.00 Very Low Very Low Very Low
Sprains And Strains 3 5.00 Very Low Very Low Very Low
Toxicity 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
On the one hand, the phosphorylation on Thr34 by protein kinase A (PKA) converts DARPP-32 into a selective inhibitor of serine/threonine protein phosphatase-1 (PP-1), thereby enhancing phosphorylation of proteins targeted by PP-1.
Negative_regulation (inhibitor) of PP-1
1) Confidence 0.08 Published 2010 Journal Frontiers in Neuroanatomy Section Body Doc Link PMC2955397 Disease Relevance 0.13 Pain Relevance 0.13
Indeed, in its activated state as pThr34-DARPP-32, it becomes a robust inhibitor of protein phosphatase 1 (PP-1), a substrate responsible for de-phosphorylation of numerous cellular targets.
Negative_regulation (inhibitor) of PP-1
2) Confidence 0.04 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2656817 Disease Relevance 0.06 Pain Relevance 0.27

General Comments

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