INT264830

Context Info Confidence 0.05 First Reported 2007 Last Reported 2007 Negated 0 Speculated 0 Reported most in Body Documents 1 Total Number 1 Disease Relevance 0.06 Pain Relevance 0.27

nucleoplasm (Ppp1ca) nucleus (Ppp1ca) cell cycle (Ppp1ca) carbohydrate metabolic process (Ppp1ca) cell division (Ppp1ca) cytoplasm (Ppp1ca)

Ppp1ca (Mus musculus)

Pain Link Frequency Relevance Heat Nucleus accumbens 10 91.84 Dopamine 2 86.12 amygdala 4 85.36 Hippocampus 9 76.32 addiction 35 65.32 Thalamus 2 36.80 cerebral cortex 2 25.04 Pyramidal cell 1 12.56 Glutamate 1 7.12 cocaine 6 5.00

Disease Link Frequency Relevance Heat Anxiety Disorder 2 55.04 Apoptosis 4 45.60 Frailty 2 29.04 Targeted Disruption 12 5.00 Drug Dependence 7 5.00 Cold Sores 7 5.00 Recurrence 4 5.00 Sprains And Strains 3 5.00 Toxicity 2 5.00 Cognitive Disorder 1 5.00

Sentences Mentioned In

Key:

Protein

Mutation

Event

Anatomy

Negation

Speculation

Pain term

Disease term

Indeed, in its activated state as pThr34-DARPP-32, it becomes a robust inhibitor of protein phosphatase 1 (PP-1), a substrate responsible for de-phosphorylation of numerous cellular targets.

Regulation (responsible) of Phosphorylation (phosphorylation) of PP-1

1) Confidence 0.05 Published 2007 Journal Current Neuropharmacology Section Body Doc Link PMC2656817 Disease Relevance 0.06 Pain Relevance 0.27

General Comments

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