INT26487

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Context Info
Confidence 0.70
First Reported 1985
Last Reported 2010
Negated 0
Speculated 3
Reported most in Body
Documents 17
Total Number 21
Disease Relevance 10.01
Pain Relevance 8.78

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (Npr1) plasma membrane (Npr1) intracellular (Npr1)
Anatomy Link Frequency
smooth muscle cells 2
visceral 1
plasma 1
smooth muscle 1
muscle fibers 1
Npr1 (Mus musculus)
Pain Link Frequency Relevance Heat
Morphine 24 99.92 Very High Very High Very High
Pain 39 99.84 Very High Very High Very High
antinociception 14 99.84 Very High Very High Very High
dorsal root ganglion 45 99.36 Very High Very High Very High
Dorsal horn neuron 2 99.08 Very High Very High Very High
Clonidine 18 98.98 Very High Very High Very High
Visceral pain 2 98.56 Very High Very High Very High
Hippocampus 25 98.44 Very High Very High Very High
Inflammation 105 98.28 Very High Very High Very High
analgesia 7 96.96 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 46 99.36 Very High Very High Very High
Nociception 28 99.24 Very High Very High Very High
Irritable Bowel Syndrome /

Irritable Bowel Syndrome Super / Visceral Pain

2 98.56 Very High Very High Very High
INFLAMMATION 134 98.28 Very High Very High Very High
Increased Venous Pressure Under Development 67 98.28 Very High Very High Very High
Neuropathic Pain 28 95.80 Very High Very High Very High
Reprotox - General 2 5 95.44 Very High Very High Very High
Stress 53 93.40 High High
Thrombosis 2 91.76 High High
Alzheimer's Dementia 38 91.72 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
The present results suggest that thiamine could produce antinociception by the activation of guanylyl cyclase mediated by cyclic guanosine monophosphate (cGMP) that may trigger the possible involvement of central and/or peripheral L-arginine/NO/cGMP pathway.
Positive_regulation (activation) of guanylyl cyclase associated with antinociception
1) Confidence 0.70 Published 2000 Journal Arzneimittelforschung Section Abstract Doc Link 10918950 Disease Relevance 0.24 Pain Relevance 0.89
We investigated the ability of carbachol and morphine to increase cGMP contents of plasma, heart, and lung and the guanylate cyclase activity of heart and lung homogenate in 1-, 2-, 3-, and 7-week-old mice.
Spec (investigated) Positive_regulation (increase) of guanylate cyclase in heart associated with morphine
2) Confidence 0.50 Published 1989 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 2558786 Disease Relevance 0 Pain Relevance 0.47
Role of guanylyl cyclase activation via thiamine in suppressing chemically-induced writhing in mouse.
Positive_regulation (activation) of guanylyl cyclase associated with pain
3) Confidence 0.50 Published 2000 Journal Arzneimittelforschung Section Title Doc Link 10918950 Disease Relevance 0.20 Pain Relevance 0.90
Inhibition of clonidine-induced increase in plasma cyclic GMP by yohimbine, hexamethonium and atropine, but not by prazosin suggests that the effect of clonidine is mediated by the central alpha 2-adrenoceptors, activating the muscarinic receptor-linked guanylate cyclase through the stimulation of vagal activity.
Positive_regulation (activating) of receptor-linked guanylate cyclase in plasma associated with clonidine
4) Confidence 0.26 Published 1986 Journal Arch Int Pharmacodyn Ther Section Abstract Doc Link 3013108 Disease Relevance 0 Pain Relevance 1.61
Therefore, we investigated the anti-nociceptive properties of linaclotide in rodent models of inflammatory and non-inflammatory visceral pain and determined whether these pharmacological effects are linked to the activation of guanylate cyclase C (GC-C).
Spec (whether) Positive_regulation (activation) of guanylate cyclase in visceral associated with nociception, visceral pain and inflammation
5) Confidence 0.24 Published 2010 Journal Neurogastroenterol. Motil. Section Abstract Doc Link 19706070 Disease Relevance 1.18 Pain Relevance 0.60
The results also indicate that the guanylate cyclase system is stimulated in the peripheral nociceptive reaction.
Positive_regulation (stimulated) of guanylate cyclase associated with nociception
6) Confidence 0.22 Published 2001 Journal Brain Res. Section Abstract Doc Link 11478933 Disease Relevance 0.47 Pain Relevance 0.83
Acute morphine treatment produced the following: (1) increases in calmodulin levels in the young and old mice while having no effect on mature levels; (2) increases in activities of guanylate cyclase of mature mice while decreasing those of the old mice; (3) no effects on activity of adenylate cyclase; (4) decreased activity of cyclic AMP-phosphodiesterase in young mice only; (5) decreased activity of Ca2+, Mg2+-ATPase in the old mice only.
Positive_regulation (increases) of guanylate cyclase associated with morphine
7) Confidence 0.22 Published 1985 Journal J. Neurochem. Section Abstract Doc Link 2857771 Disease Relevance 0.07 Pain Relevance 0.40
Further, the ameliorating effects of (+) SKF 10,047 on the impairment of spontaneous alternation behavior may be mediated through activation of guanylate cyclase, but not nitric oxide synthase in the hippocampus of mice.
Positive_regulation (activation) of guanylate cyclase in hippocampus associated with hippocampus
8) Confidence 0.20 Published 2000 Journal Neuropharmacology Section Abstract Doc Link 10974323 Disease Relevance 0 Pain Relevance 0.35
Next, we provide evidence that production of iNOS results in the activation of guanylyl cyclase leading to the production of cGMP and smooth muscle relaxation.
Positive_regulation (activation) of guanylyl cyclase in smooth muscle
9) Confidence 0.19 Published 2003 Journal Verh. K. Acad. Geneeskd. Belg. Section Abstract Doc Link 14671847 Disease Relevance 0.66 Pain Relevance 0.31
We investigated the ability of carbachol and morphine to increase cGMP contents of plasma, heart, and lung and the guanylate cyclase activity of heart and lung homogenate in 1-, 2-, 3-, and 7-week-old mice.
Spec (investigated) Positive_regulation (increase) of guanylate cyclase in lung associated with morphine
10) Confidence 0.17 Published 1989 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 2558786 Disease Relevance 0 Pain Relevance 0.47
A gaseous molecular, NO diffuses out from the DRG neurons or primary afferent terminals and stimulates guanylyl cyclase in neighboring DRG or dorsal horn neurons to form cyclic guanosine monophosphate (cGMP) [2]. cGMP activates several intracellular processes, including cGMP-dependent protein kinase (PKG), ion channels, and phosphodiesterases (PDEs) [37].
Positive_regulation (stimulates) of guanylyl cyclase in neurons associated with dorsal root ganglion and dorsal horn neuron
11) Confidence 0.10 Published 2007 Journal Mol Pain Section Body Doc Link PMC2089056 Disease Relevance 1.64 Pain Relevance 0.78
NO has long been considered to act largely through cGMP formed by activation of soluble guanylyl cyclase and subsequent cGK activation in the nervous system [5].
Positive_regulation (activation) of soluble guanylyl cyclase in nervous system
12) Confidence 0.05 Published 2009 Journal Mol Pain Section Body Doc Link PMC2762960 Disease Relevance 0.05 Pain Relevance 0.19
Once produced, NO diffusing in vascular smooth muscle cells, activates the guanylate cyclase (cGMP), which induces relaxation and then vasodilation.
Positive_regulation (activates) of guanylate cyclase in smooth muscle cells associated with increased venous pressure under development
13) Confidence 0.04 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2464748 Disease Relevance 0.70 Pain Relevance 0.04
Phosphodiesterase 5 (PDE-5) was the first identified selective cGMP esterase in the cardiovascular system and is the major isoform involved in the hydrolysis of the cGMP pools generated by the activation of soluble guanylyl cyclase.
Positive_regulation (activation) of soluble guanylyl cyclase in cardiovascular system
14) Confidence 0.04 Published 2010 Journal Curr Hypertens Rep Section Body Doc Link PMC2910890 Disease Relevance 1.24 Pain Relevance 0.04
Increased NO levels lead to the activation of guanylate cyclase and elevated production of cyclic guanosine monophosphate (cGMP) [73], which subsequently affects contractile function, glucose metabolism [74], and Ca2+ mobilization in muscle fibers [75]. nNOS also acts as an effector of agrin-induced postsynaptic differentiation at the NMJ (reviewed in [76, 77]).
Positive_regulation (activation) of guanylate cyclase in muscle fibers
15) Confidence 0.03 Published 2009 Journal Mol Neurobiol Section Body Doc Link PMC2840664 Disease Relevance 0.24 Pain Relevance 0.03
Superoxide may also decrease the effective cellular level of nitric oxide below that required for guanylyl cyclase activation [40].
Positive_regulation (required) of guanylyl cyclase
16) Confidence 0.03 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2386519 Disease Relevance 0.31 Pain Relevance 0.09
Nitric oxide directly enters the smooth muscle cell and activates soluble guanylyl cyclase, thereby raising intracellular cGMP.
Positive_regulation (activates) of guanylyl cyclase in smooth muscle cell
17) Confidence 0.03 Published 2008 Journal Journal of Clinical Biochemistry and Nutrition Section Body Doc Link PMC2386519 Disease Relevance 0.33 Pain Relevance 0.03
By contrast, activators of soluble guanylyl cyclase target the enzyme when its heme is oxidized and no longer responsive to NO.
Positive_regulation (activators) of soluble guanylyl cyclase
18) Confidence 0.02 Published 2010 Journal Curr Hypertens Rep Section Body Doc Link PMC2910890 Disease Relevance 0.84 Pain Relevance 0.13
These two diterpenoids may exert their vasorelaxant activities through the activation of the NOS and guanylyl cyclase for NO release from endothelial cells [105].
Positive_regulation (activation) of guanylyl cyclase in endothelial cells
19) Confidence 0.02 Published 2010 Journal Chin Med Section Body Doc Link PMC2881933 Disease Relevance 0.29 Pain Relevance 0.05
Some effects of NO are mediated by the activation of the soluble guanylyl cyclase (sGC) and the subsequent increase in intracellular cGMP levels.
Positive_regulation (activation) of guanylyl cyclase
20) Confidence 0.01 Published 2009 Journal Mol Pain Section Body Doc Link PMC2731738 Disease Relevance 0.11 Pain Relevance 0.09

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