INT26488

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Context Info
Confidence 0.39
First Reported 1989
Last Reported 2009
Negated 0
Speculated 0
Reported most in Abstract
Documents 4
Total Number 4
Disease Relevance 0.88
Pain Relevance 1.56

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (Npr1) plasma membrane (Npr1) intracellular (Npr1)
Anatomy Link Frequency
spinal cord 2
Npr1 (Mus musculus)
Pain Link Frequency Relevance Heat
nociceptor 4 100.00 Very High Very High Very High
Neuronal nitric oxide synthase 2 100.00 Very High Very High Very High
nMDA receptor 1 99.72 Very High Very High Very High
Spinal cord 34 99.60 Very High Very High Very High
opioid receptor 2 99.52 Very High Very High Very High
Morphine 5 99.28 Very High Very High Very High
Pain 8 86.40 High High
Neurotransmitter 5 72.92 Quite High
Central nervous system 2 66.32 Quite High
Dorsal horn 1 61.48 Quite High
Disease Link Frequency Relevance Heat
Nociception 14 98.72 Very High Very High Very High
Pain 10 86.40 High High
Depression 1 55.80 Quite High
Neuropathic Pain 2 39.04 Quite Low
Hyperalgesia 2 38.48 Quite Low
Pheochromocytoma 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
These changes in the effects of carbachol and morphine may be the result of developmental changes of the muscarinic receptor--guanylate cyclase system and opioid receptors.
Regulation (changes) of guanylate cyclase associated with opioid receptor and morphine
1) Confidence 0.39 Published 1989 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 2558786 Disease Relevance 0 Pain Relevance 0.49
Regulation and immunhistochemical localization of nitric oxide synthases and soluble guanylyl cyclase in mouse spinal cord following nociceptive stimulation.
Regulation (Regulation) of soluble guanylyl cyclase in spinal cord associated with nociception, nociceptor and spinal cord
2) Confidence 0.16 Published 2000 Journal Neurosci. Lett. Section Title Doc Link 10925177 Disease Relevance 0.18 Pain Relevance 0.39
The localization and regulation of neuronal nitric oxide synthase (nNOS), inducible nitric oxide synthase (iNOS) and soluble guanylyl cyclase (sGC) were assessed in the spinal cord of mice stimulated by an intraplantar injection of zymosan.
Regulation (regulation) of soluble guanylyl cyclase in spinal cord associated with spinal cord and neuronal nitric oxide synthase
3) Confidence 0.07 Published 2000 Journal Neurosci. Lett. Section Abstract Doc Link 10925177 Disease Relevance 0.15 Pain Relevance 0.18
Through this reversible post-translational modification, NO is able to regulate the function of many target enzymes, ion channels, and structural proteins including cyclooxygenase-2 [19], soluble guanylyl cyclase [20], NMDA receptors [21-23], actin [17,24], and other pathogenic proteins [25,26].
Regulation (regulate) of soluble guanylyl cyclase associated with nmda receptor
4) Confidence 0.02 Published 2009 Journal Mol Pain Section Body Doc Link PMC2762960 Disease Relevance 0.55 Pain Relevance 0.50

General Comments

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