INT264881

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.42
First Reported 2008
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 7
Disease Relevance 9.52
Pain Relevance 1.85

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (CXCL13) extracellular space (CXCL13) extracellular region (CXCL13)
cell-cell signaling (CXCL13)
Anatomy Link Frequency
monocyte 1
B cell 1
eosinophil 1
articular cartilage 1
CXCL13 (Homo sapiens)
Pain Link Frequency Relevance Heat
chemokine 28 100.00 Very High Very High Very High
Osteoarthritis 50 99.74 Very High Very High Very High
Multiple sclerosis 136 99.00 Very High Very High Very High
Inflammation 89 95.24 Very High Very High Very High
imagery 80 94.20 High High
intrathecal 40 91.04 High High
headache 4 15.84 Low Low
aspirin 10 5.00 Very Low Very Low Very Low
cytokine 10 5.00 Very Low Very Low Very Low
Spinal cord 4 5.00 Very Low Very Low Very Low
Disease Link Frequency Relevance Heat
Osteoarthritis 52 99.74 Very High Very High Very High
Demyelinating Disease 136 99.00 Very High Very High Very High
Syndrome 304 98.16 Very High Very High Very High
INFLAMMATION 93 95.24 Very High Very High Very High
Rhinitis 124 93.84 High High
Polyps 26 93.08 High High
Eczema 62 90.48 High High
Measles 12 89.60 High High
Togavirus Infection 12 89.24 High High
Herpes Zoster 12 88.76 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Consequently, this study should be considered a pilot study that warrants further validation of CSF CXCL13 as a prognostic marker in a multi-center approach on a large cohort of patients with CIS.
Localization (validation) of CXCL13 associated with syndrome
1) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2916843 Disease Relevance 0.64 Pain Relevance 0.16
In conclusion, this study underlines the prognostic relevance of CXCL13 to predict conversion to MS in patients with CIS.
Localization (relevance) of CXCL13 associated with multiple sclerosis and syndrome
2) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2916843 Disease Relevance 0.98 Pain Relevance 0.19
25 [13]) and provided no longitudinal clinical data on the prognostic relevance of CSF CXCL13 regarding conversion to MS.
Localization (relevance) of CXCL13 associated with multiple sclerosis
3) Confidence 0.42 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2916843 Disease Relevance 1.84 Pain Relevance 0.51
We aimed to evaluate the relevance of the B cell chemoattractant CXCL13 as a prognostic marker in patients with clinically isolated syndrome (CIS) regarding conversion to MS, and to compare it to Barkhof criteria in magnetic resonance imaging (MRI), oligoclonal bands (OCB) and the polyspecific intrathecal B cell response against measles, rubella and varicella zoster virus (MRZR).


Localization (relevance) of CXCL13 in B cell associated with multiple sclerosis, measles, syndrome, herpes zoster, togavirus infection, imagery and intrathecal
4) Confidence 0.42 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2916843 Disease Relevance 1.37 Pain Relevance 0.35
These included increased transcription of chemokines localized to chromosome 17q11.2 (CCL13, CCL2, CCL8, and CCL11) that favor eosinophil and monocyte chemotaxis and chemokines (CCL18, CCL22, and CXCL13) that alternatively-activated monocyte-derived cells have been shown to produce.
Localization (localized) of CXCL13 in monocyte associated with chemokine
5) Confidence 0.34 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2897889 Disease Relevance 1.89 Pain Relevance 0.18
OA osteoblasts release more IL-6, CXCL12, CXCL13 and leptin that can also directly modulate COLLI synthesis, promote articular cartilage degradation and contribute to inflammatory state observed in OA.
Localization (release) of CXCL13 in articular cartilage associated with inflammation and osteoarthritis
6) Confidence 0.25 Published 2008 Journal J Orthop Traumatol Section Body Doc Link PMC2656961 Disease Relevance 0.91 Pain Relevance 0.29
These included increased transcription of chemokines localized to chromosome 17q11.2 (CCL13, CCL2, CCL8, and CCL11) that favor eosinophil and monocyte chemotaxis and chemokines (CCL18, CCL22, and CXCL13) that alternatively-activated monocyte-derived cells have been shown to produce.
Localization (localized) of CXCL13 in eosinophil associated with chemokine
7) Confidence 0.12 Published 2010 Journal PLoS ONE Section Abstract Doc Link PMC2897889 Disease Relevance 1.89 Pain Relevance 0.18

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox