INT26489

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Context Info
Confidence 0.59
First Reported 1989
Last Reported 2010
Negated 0
Speculated 0
Reported most in Abstract
Documents 15
Total Number 17
Disease Relevance 5.70
Pain Relevance 6.79

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

lyase activity (Npr1) plasma membrane (Npr1) intracellular (Npr1)
Anatomy Link Frequency
cardiomyocyte 1
BNP 1
hindlimb 1
adipocytes 1
lung 1
Npr1 (Mus musculus)
Pain Link Frequency Relevance Heat
Dopamine 156 99.72 Very High Very High Very High
analgesia 9 98.84 Very High Very High Very High
diabetic neuropathy 1 98.60 Very High Very High Very High
nMDA receptor 7 97.52 Very High Very High Very High
Morphine 19 97.12 Very High Very High Very High
dorsal root ganglion 45 97.04 Very High Very High Very High
anesthesia 8 93.92 High High
Antinociceptive 1 91.08 High High
Spinal cord 106 89.52 High High
intrathecal 16 89.36 High High
Disease Link Frequency Relevance Heat
Obesity 5 99.84 Very High Very High Very High
Anaphylaxis 4 99.84 Very High Very High Very High
Targeted Disruption 20 99.56 Very High Very High Very High
Pressure Volume 2 Under Development 7 99.32 Very High Very High Very High
Diabetic Neuropathy 1 98.60 Very High Very High Very High
Hypersensitivity 30 97.68 Very High Very High Very High
Ganglion Cysts 45 97.04 Very High Very High Very High
Natriuresis 14 96.20 Very High Very High Very High
Nervous System Injury 73 91.64 High High
INFLAMMATION 5 88.48 High High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
In the absence of pressure overload, basal and BNP-stimulated guanylyl cyclase activity assessed in cardiac membrane fractions was reduced.
Negative_regulation (reduced) of guanylyl cyclase in BNP
1) Confidence 0.59 Published 2005 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 15778276 Disease Relevance 0.73 Pain Relevance 0.16
The basal cGMP contents in heart and lung and their rise induced by carbachol, as well as the guanylate cyclase activity of these organs, were decreased in 7-week-old mice.
Negative_regulation (decreased) of guanylate cyclase in heart
2) Confidence 0.59 Published 1989 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 2558786 Disease Relevance 0 Pain Relevance 0.50
To attenuate cardiomyocyte NPRA activity, transgenic mice with cardiac specific expression of a dominant-negative (DN-NPRA) mutation (HCAT D 893A) in the NPRA receptor were created.
Negative_regulation (attenuate) of NPRA in cardiomyocyte associated with targeted disruption
3) Confidence 0.38 Published 2005 Journal Am. J. Physiol. Heart Circ. Physiol. Section Abstract Doc Link 15778276 Disease Relevance 0.60 Pain Relevance 0.08
Methylene blue, which inhibits guanylyl cyclase and NO synthase, attenuated KA sensitization, suggesting that cyclic GMP synthesis may also be involved in this phenomenon.
Negative_regulation (inhibits) of guanylyl cyclase
4) Confidence 0.33 Published 1995 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7473137 Disease Relevance 0.08 Pain Relevance 0.56
The effect of inhibiting "downstream" consequences of NMDA receptor stimulation with 7-nitroindazole, an inhibitor of the neuronal form of nitric oxide synthase (NOS), and methylene blue, an inhibitor of the nitric oxide (NO)-sensitive soluble guanylyl cyclase, on electrically precipitated tonic hindlimb extension in mice was studied.
Negative_regulation (inhibitor) of guanylyl cyclase in hindlimb associated with nmda receptor
5) Confidence 0.28 Published 1995 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 7617724 Disease Relevance 0 Pain Relevance 0.05
Sildenafil-induced analgesia was significantly blocked by methylene blue (1 mg/kg), a guanylate cyclase inhibitor, but was not reversed by L-NAME (10 mg/kg), a nitric oxide synthase inhibitor.
Negative_regulation (inhibitor) of guanylate cyclase associated with analgesia
6) Confidence 0.26 Published 2001 Journal Brain Res. Section Abstract Doc Link 11478933 Disease Relevance 0.79 Pain Relevance 0.92
In addition, the NO synthase inhibitor, L-NAME and the guanylate cyclase inhibitor, ODQ were incapable of blocking the phentolamine-induced effects.
Negative_regulation (inhibitor) of guanylate cyclase
7) Confidence 0.23 Published 2010 Journal Arch. Pharm. Res. Section Abstract Doc Link 20361315 Disease Relevance 0 Pain Relevance 0.09
The basal cGMP contents in heart and lung and their rise induced by carbachol, as well as the guanylate cyclase activity of these organs, were decreased in 7-week-old mice.
Negative_regulation (decreased) of guanylate cyclase in lung
8) Confidence 0.20 Published 1989 Journal Can. J. Physiol. Pharmacol. Section Abstract Doc Link 2558786 Disease Relevance 0 Pain Relevance 0.50
The effect of inhibitors of soluble guanylate cyclase on anaphylactic hypotension were studied with either methylene blue (3.0 mg/kg) or 1H-[1,2,4]oxadiazole[4,3-a]quinoxalin-1-one (10 mg/kg).
Negative_regulation (inhibitors) of guanylate cyclase associated with pressure volume 2 under development and anaphylaxis
9) Confidence 0.17 Published 2007 Journal J. Pharmacol. Sci. Section Abstract Doc Link 17598952 Disease Relevance 0.97 Pain Relevance 0
This effect could be reversed by inhibition of NOS and guanylyl cyclase [42].
Negative_regulation (inhibition) of guanylyl cyclase
10) Confidence 0.13 Published 2007 Journal Mol Pain Section Body Doc Link PMC2089056 Disease Relevance 1.69 Pain Relevance 0.96
The fast response was abolished by the nitric oxide (NO) synthesis inhibitor L-N(G)-nitro arginine (L-NNA) or by the guanylate cyclase inhibitor (ODQ), the sustained one by alpha-chymotrypsin. alpha-Chymotrypsin also increased the amplitude of the EFS-induced fast relaxation.
Negative_regulation (inhibitor) of guanylate cyclase inhibitor
11) Confidence 0.09 Published 2001 Journal Regul. Pept. Section Abstract Doc Link 11179775 Disease Relevance 0 Pain Relevance 0.13
The inhibition by SNAP was not attenuated by ODQ, a soluble guanylyl cyclase inhibitor; KT5823, a cGK inhibitor; or glibenclamide, an ATP-sensitive K+ channel blocker (Figure 3A).
Negative_regulation (inhibitor) of soluble guanylyl cyclase
12) Confidence 0.05 Published 2009 Journal Mol Pain Section Body Doc Link PMC2762960 Disease Relevance 0 Pain Relevance 0.16
To clarify whether the suppressive effect of SNAP on the dopamine release was mediated by the NO/cGMP/cGK signaling pathway, we examined whether the suppressive effect by SNAP could be attenuated by ODQ, a guanylyl cyclase blocker; KT5823, an inhibitor of cGK; or glibenclamide, an ATP-sensitive K+ channel blocker [32].
Negative_regulation (blocker) of guanylyl cyclase associated with dopamine
13) Confidence 0.04 Published 2009 Journal Mol Pain Section Body Doc Link PMC2762960 Disease Relevance 0 Pain Relevance 0.31
The inhibition of dopamine release was not attenuated by inhibitors of soluble guanylyl cyclase and cGMP-dependent protein kinase.


Negative_regulation (inhibitors) of soluble guanylyl cyclase associated with dopamine
14) Confidence 0.03 Published 2009 Journal Mol Pain Section Abstract Doc Link PMC2762960 Disease Relevance 0.24 Pain Relevance 0.42
Methylene blue (MB), a guanylate cyclase (GC) inhibitor, also dose-dependently prevented the potentiative effect of bLF.
Negative_regulation (inhibitor) of cyclase
15) Confidence 0.02 Published 2006 Journal Brain Res. Section Abstract Doc Link 16380099 Disease Relevance 0.06 Pain Relevance 1.27
The receptors mediate inhibition of adenyl cyclase in adipocytes and thereby block lipolysis, accounting for the marked reduction of free fatty acids caused by niacin.
Negative_regulation (inhibition) of adenyl cyclase in adipocytes associated with obesity
16) Confidence 0.01 Published 2008 Journal Vascular Health and Risk Management Section Body Doc Link PMC2605342 Disease Relevance 0.46 Pain Relevance 0
To determine the mechanism of SNAP-mediated DA release, the guanylyl cyclase (GC) inhibitor LY 83583 (100 microM) was administered 100 min before and during the SNAP pulse.
Negative_regulation (inhibitor) of guanylyl cyclase associated with dopamine
17) Confidence 0.01 Published 1996 Journal J. Neurochem. Section Abstract Doc Link 8780025 Disease Relevance 0.09 Pain Relevance 0.66

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