INT2649

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Context Info
Confidence 0.62
First Reported 1979
Last Reported 2010
Negated 69
Speculated 89
Reported most in Abstract
Documents 433
Total Number 524
Disease Relevance 146.05
Pain Relevance 330.95

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

extracellular space (Calca) aging (Calca) extracellular region (Calca)
nucleus (Calca) intracellular (Calca) cytoplasm (Calca)
Anatomy Link Frequency
nerve 35
neurons 22
plasma 20
spinal 17
dorsal root ganglia 15
Calca (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Calcitonin gene-related peptide 3561 100.00 Very High Very High Very High
qutenza 1251 100.00 Very High Very High Very High
substance P 755 100.00 Very High Very High Very High
Nerve growth factor 605 100.00 Very High Very High Very High
Pain 598 100.00 Very High Very High Very High
Spinal cord 481 100.00 Very High Very High Very High
Inflammation 463 100.00 Very High Very High Very High
Neuropeptide 414 100.00 Very High Very High Very High
antagonist 328 100.00 Very High Very High Very High
Glutamate 233 100.00 Very High Very High Very High
Disease Link Frequency Relevance Heat
Ganglion Cysts 587 100.00 Very High Very High Very High
INFLAMMATION 409 100.00 Very High Very High Very High
Nociception 230 100.00 Very High Very High Very High
Hyperalgesia 149 100.00 Very High Very High Very High
Arthritis 135 100.00 Very High Very High Very High
Osteoporosis 83 100.00 Very High Very High Very High
Urological Neuroanatomy 78 100.00 Very High Very High Very High
Depression 26 100.00 Very High Very High Very High
Cv Unclassified Under Development 17 100.00 Very High Very High Very High
Experimental Arthritis 14 100.00 Very High Very High Very High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
When endogenous CGRP was depleted, although the positive chronotropic and inotropic effects of piperine and capsaicin were abolished, the effects of CGRP and isoproterenol were not affected.
Neg (not) Regulation (affected) of CGRP associated with qutenza and calcitonin gene-related peptide
1) Confidence 0.62 Published 1989 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 2783973 Disease Relevance 0 Pain Relevance 1.30
AIMS: To investigate changes in calcitonin gene-related peptide (CGRP)-like immunoreactivity (CGRP-LI) in the rat masseter muscle and brain after the unilateral experimental induction of masseter myositis.
Spec (investigate) Regulation (changes) of CGRP in masseter associated with myositis and calcitonin gene-related peptide
2) Confidence 0.62 Published 2004 Journal J Orofac Pain Section Abstract Doc Link 15509004 Disease Relevance 0.17 Pain Relevance 0.19
AIMS: To investigate changes in calcitonin gene-related peptide (CGRP)-like immunoreactivity (CGRP-LI) in the rat masseter muscle and brain after the unilateral experimental induction of masseter myositis.
Spec (investigate) Regulation (changes) of calcitonin gene-related peptide in masseter associated with myositis and calcitonin gene-related peptide
3) Confidence 0.62 Published 2004 Journal J Orofac Pain Section Abstract Doc Link 15509004 Disease Relevance 0.17 Pain Relevance 0.19
The influence of calcitonin gene-related peptide (CGRP) on rat uterine activity was examined in concert with the anatomical distribution of CGRP-like immunoreactivity in the uterus.
Regulation (influence) of calcitonin gene-related peptide in uterine associated with calcitonin gene-related peptide
4) Confidence 0.62 Published 1990 Journal Peptides Section Abstract Doc Link 2381876 Disease Relevance 0 Pain Relevance 0.26
The influence of calcitonin gene-related peptide (CGRP) on rat uterine activity was examined in concert with the anatomical distribution of CGRP-like immunoreactivity in the uterus.
Regulation (influence) of CGRP in uterine associated with calcitonin gene-related peptide
5) Confidence 0.62 Published 1990 Journal Peptides Section Abstract Doc Link 2381876 Disease Relevance 0 Pain Relevance 0.27
Increased calcitonin gene-related peptide (CGRP), substance P, and enkephalin immunoreactivities in dorsal spinal cord and loss of CGRP-immunoreactive motoneurons in arthritic rats depend on intact peripheral nerve supply.
Regulation (immunoreactivities) of CGRP in dorsal associated with enkephalin, arthritis, spinal cord, substance p and calcitonin gene-related peptide
6) Confidence 0.62 Published 1991 Journal J. Mol. Neurosci. Section Title Doc Link 1715733 Disease Relevance 0.47 Pain Relevance 1.40
Adrenergic modulation of calcitonin gene-related peptide (CGRP)-containing nerve-mediated vasodilation in the rat mesenteric resistance vessel.
Regulation (modulation) of CGRP in nerve associated with increased venous pressure under development and calcitonin gene-related peptide
7) Confidence 0.62 Published 1990 Journal Brain Res. Section Title Doc Link 2154285 Disease Relevance 0.33 Pain Relevance 0.51
Adrenergic modulation of calcitonin gene-related peptide (CGRP)-containing nerve-mediated vasodilation in the rat mesenteric resistance vessel.
Regulation (modulation) of calcitonin gene-related peptide in nerve associated with increased venous pressure under development and calcitonin gene-related peptide
8) Confidence 0.62 Published 1990 Journal Brain Res. Section Title Doc Link 2154285 Disease Relevance 0.33 Pain Relevance 0.51
Previous studies have shown that calcitonin gene-related peptide (CGRP) mRNA steady-state levels and CGRP immunoreactivity in motoneurons of the spinal nucleus of the bulbocavernosus (SNB) are inversely related to the gonadal steroid environment in male rats.
Regulation (immunoreactivity) of CGRP in motoneurons associated with calcitonin gene-related peptide
9) Confidence 0.62 Published 1992 Journal Brain Res. Mol. Brain Res. Section Abstract Doc Link 1315918 Disease Relevance 0 Pain Relevance 0.31
Tolerance to morphine did not alter the levels of CGRP in any brain region or in the spinal cord of the rat.
Neg (not) Regulation (alter) of CGRP in spinal cord associated with tolerance, spinal cord, calcitonin gene-related peptide and morphine
10) Confidence 0.62 Published 1992 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 1335576 Disease Relevance 0 Pain Relevance 1.36
These data are consistent with the hypothesis that CGRP acts as a modulatory peptide in opiate-sensitive systems and tonic opioid control of CGRP levels exists in brain.
Regulation (control) of CGRP in brain associated with opiate, opioid and calcitonin gene-related peptide
11) Confidence 0.62 Published 1992 Journal Pharmacol. Biochem. Behav. Section Abstract Doc Link 1335576 Disease Relevance 0 Pain Relevance 1.51
The beta-adrenergic blocking agent metoprolol, while obliterating the increase in the force and rate of contraction evoked by noradrenaline in the right atrium, did not significantly change the action of CGRP.
Neg (not) Regulation (change) of CGRP in right atrium associated with noradrenaline and calcitonin gene-related peptide
12) Confidence 0.62 Published 1986 Journal Endocrinology Section Abstract Doc Link 3013594 Disease Relevance 0 Pain Relevance 0.91
The effect of sympathectomy on the calcitonin gene-related peptide (CGRP) level in the rat primary trigeminal sensory neurone was investigated.
Spec (investigated) Regulation (effect) of calcitonin gene-related peptide associated with calcitonin gene-related peptide
13) Confidence 0.62 Published 1985 Journal Brain Res. Section Abstract Doc Link 3877546 Disease Relevance 0.17 Pain Relevance 0.38
The effect of sympathectomy on the calcitonin gene-related peptide (CGRP) level in the rat primary trigeminal sensory neurone was investigated.
Spec (investigated) Regulation (effect) of CGRP associated with calcitonin gene-related peptide
14) Confidence 0.62 Published 1985 Journal Brain Res. Section Abstract Doc Link 3877546 Disease Relevance 0.17 Pain Relevance 0.38
Vascular contents of norepinephrine, calcitonin gene-related peptide, neuropeptide Y and substance P were not altered by chronic nicotine treatment.
Neg (not) Regulation (altered) of calcitonin associated with nicotine, neuropeptide, substance p and calcitonin gene-related peptide
15) Confidence 0.62 Published 1994 Journal J. Pharmacol. Exp. Ther. Section Abstract Doc Link 7996418 Disease Relevance 0.14 Pain Relevance 0.78
In this report, the effects of antidromic trigeminal stimulation on levels of calcitonin gene-related peptide (CGRP) in plasma were examined in the superior sagittal sinus and the effects of drugs that have been shown previously to block extravasation of neurogenic plasma determined.
Spec (examined) Regulation (effects) of CGRP in plasma associated with calcitonin gene-related peptide
16) Confidence 0.62 Published 1991 Journal Neuropharmacology Section Abstract Doc Link 1663596 Disease Relevance 0.35 Pain Relevance 0.56
In this report, the effects of antidromic trigeminal stimulation on levels of calcitonin gene-related peptide (CGRP) in plasma were examined in the superior sagittal sinus and the effects of drugs that have been shown previously to block extravasation of neurogenic plasma determined.
Spec (examined) Regulation (effects) of calcitonin gene-related peptide in plasma associated with calcitonin gene-related peptide
17) Confidence 0.62 Published 1991 Journal Neuropharmacology Section Abstract Doc Link 1663596 Disease Relevance 0.35 Pain Relevance 0.56
This study was designed to investigate the effects of multiple denervation procedures on calcitonin gene-related peptide- and substance P-immunoreactive neurons in sympathetic and sensory cranial ganglia and in selected targets.
Spec (investigate) Regulation (effects) of calcitonin in cranial ganglia associated with substance p and calcitonin gene-related peptide
18) Confidence 0.62 Published 1992 Journal Cell Tissue Res. Section Abstract Doc Link 1378354 Disease Relevance 0 Pain Relevance 0.57
In the iris, capsaicin treatment had little effect on calcitonin gene-related peptide- and substance P-immunoreactive nerves, suggesting that in rats the majority of these fibres originate from capsaicin-insensitive neurons.
Neg (little) Regulation (effect) of calcitonin in iris associated with qutenza, substance p and calcitonin gene-related peptide
19) Confidence 0.62 Published 1992 Journal Cell Tissue Res. Section Abstract Doc Link 1378354 Disease Relevance 0 Pain Relevance 1.13
Differential effects of calcitonin gene-related peptide and calcitonin gene-related peptide 8-37 upon responses to N-methyl-D-aspartate or (R, S)-alpha-amino-3-hydroxy-5-methylisoxazole-4-propionate in spinal nociceptive neurons with knee joint input in the rat.
Regulation (effects) of calcitonin gene-related peptide in spinal associated with nociception, nociceptor and calcitonin gene-related peptide
20) Confidence 0.62 Published 2000 Journal Neuroscience Section Title Doc Link 10924961 Disease Relevance 0.35 Pain Relevance 0.75

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