INT264905

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Context Info
Confidence 0.50
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 2
Disease Relevance 0.12
Pain Relevance 1.19

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cnr1) aging (Cnr1) plasma membrane (Cnr1)
signal transducer activity (Cnr1)
Anatomy Link Frequency
brain 2
Cnr1 (Mus musculus)
Pain Link Frequency Relevance Heat
Analgesic 120 98.64 Very High Very High Very High
opioid receptor 10 96.84 Very High Very High Very High
Opioid 20 80.80 Quite High
tolerance 98 80.56 Quite High
Cannabinoid 108 79.84 Quite High
agonist 118 77.84 Quite High
mu opioid receptor 52 74.88 Quite High
midbrain 4 73.12 Quite High
Rostral ventromedial medulla 8 68.40 Quite High
substantia gelatinosa 2 60.88 Quite High
Disease Link Frequency Relevance Heat
Urological Neuroanatomy 20 68.96 Quite High
Nociception 6 52.72 Quite High
Bordatella Infection 8 5.00 Very Low Very Low Very Low
Pain 6 5.00 Very Low Very Low Very Low
Targeted Disruption 2 5.00 Very Low Very Low Very Low
Adhesions 2 5.00 Very Low Very Low Very Low
Cognitive Disorder 2 5.00 Very Low Very Low Very Low
Decapitation 2 5.00 Very Low Very Low Very Low
Hypothermia 2 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Methanandamide induced minimal internalization of CB1Rs in the brain, but it did promote analgesic desensitization.
Positive_regulation (induced) of CB1Rs Binding (internalization) of in brain associated with analgesic
1) Confidence 0.50 Published 2009 Journal Mol Pain Section Body Doc Link PMC2657119 Disease Relevance 0 Pain Relevance 0.70
M, promoted the internalization of the CB1Rs (Fig. 2C and 2D).
Positive_regulation (promoted) of CB1Rs Binding (internalization) of
2) Confidence 0.44 Published 2009 Journal Mol Pain Section Body Doc Link PMC2657119 Disease Relevance 0.12 Pain Relevance 0.49

General Comments

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