INT26491

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Context Info
Confidence 0.58
First Reported 1983
Last Reported 1997
Negated 0
Speculated 0
Reported most in Abstract
Documents 7
Total Number 8
Disease Relevance 2.07
Pain Relevance 2.15

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

Anatomy Link Frequency
fat 2
sympathetic 2
Mln (Rattus norvegicus)
Pain Link Frequency Relevance Heat
Serotonin 3 100.00 Very High Very High Very High
Somatostatin 5 99.64 Very High Very High Very High
antagonist 2 99.40 Very High Very High Very High
agonist 2 99.10 Very High Very High Very High
Morphine 7 97.32 Very High Very High Very High
tetrodotoxin 6 96.92 Very High Very High Very High
Chronic pancreatitis 3 96.16 Very High Very High Very High
Spinal cord 8 96.00 Very High Very High Very High
abdominal pain 2 77.44 Quite High
Cholecystokinin 3 50.00 Quite Low
Disease Link Frequency Relevance Heat
Pancreatitis 3 96.16 Very High Very High Very High
Frailty 8 96.00 Very High Very High Very High
Congenital Anomalies 3 91.68 High High
Constipation 2 79.32 Quite High
Ileus 2 78.60 Quite High
Abdominal Pain 2 77.44 Quite High
Gastrointestinal Disease 2 76.44 Quite High
Diarrhoea 3 76.00 Quite High
Cancer 1 72.88 Quite High
Increased Venous Pressure Under Development 1 70.32 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Both phenylephrine and octreotide decreased the release of motilin stimulated by carbachol in a jejunal segment pretreated and denervated with tetrodotoxin.
Negative_regulation (decreased) of Localization (release) of motilin associated with tetrodotoxin
1) Confidence 0.58 Published 1997 Journal Am. J. Physiol. Section Abstract Doc Link 9038869 Disease Relevance 0 Pain Relevance 0.65
Muscarinie agonist and antagonist, respectively, increased and decreased the release of motilin.
Negative_regulation (decreased) of Localization (release) of motilin associated with antagonist and agonist
2) Confidence 0.50 Published 1997 Journal Am. J. Physiol. Section Abstract Doc Link 9038869 Disease Relevance 0 Pain Relevance 0.49
These results suggest that muscarinic receptors are present on the motilin cell membrane and that acetylcholine is a major regulator of motilin release.
Negative_regulation (regulator) of Localization (release) of motilin
3) Confidence 0.36 Published 1993 Journal Peptides Section Abstract Doc Link 8483799 Disease Relevance 0 Pain Relevance 0.22
We hypothesized that abdominal sympathetic pathways provide tonic inhibition of peptide YY and motilin release and that postprandial increases in these gut hormones are mediated through spinal pathways.
Negative_regulation (inhibition) of Localization (release) of motilin in sympathetic
4) Confidence 0.32 Published 1995 Journal Am J Phys Med Rehabil Section Abstract Doc Link 7576409 Disease Relevance 0.64 Pain Relevance 0.20
RESULTS: The IBS patients had reduced motilin secretion after both water intake and the fat meal.
Negative_regulation (reduced) of Localization (secretion) of motilin in fat
5) Confidence 0.24 Published 1996 Journal Scand. J. Gastroenterol. Section Body Doc Link 8938905 Disease Relevance 0 Pain Relevance 0
In fasting studies, there was a trend (P = 0.23) toward increased fasting serum motilin in paraplegic patients, and this result did not support tonic inhibition of motilin release.
Negative_regulation (inhibition) of Localization (release) of motilin
6) Confidence 0.23 Published 1995 Journal Am J Phys Med Rehabil Section Abstract Doc Link 7576409 Disease Relevance 0.56 Pain Relevance 0.19
Since MLI is known to initiate the formation of the interdigestive migrating motor complexes, diminished motilin release secondary to pancreatic exocrine deficiency may result in disordered gastrointestinal motor activity in patients with chronic pancreatitis.
Negative_regulation (diminished) of Localization (release) of motilin associated with chronic pancreatitis
7) Confidence 0.05 Published 1983 Journal J. Clin. Endocrinol. Metab. Section Abstract Doc Link 6311858 Disease Relevance 0.33 Pain Relevance 0.27
It can suppress the secretion of serotonin, as well as the gastroenteropancreatic peptides gastrin, vasoactive intestinal peptide (VIP), insulin, glucagon, secretin, motilin, and pancreatic polypeptide.
Negative_regulation (suppress) of Localization (secretion) of motilin associated with serotonin
8) Confidence 0.03 Published 1989 Journal Conn Med Section Abstract Doc Link 2558839 Disease Relevance 0.54 Pain Relevance 0.14

General Comments

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