INT264929

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Context Info
Confidence 0.18
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Body
Documents 1
Total Number 3
Disease Relevance 1.71
Pain Relevance 2.89

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Cnr1, Gnaz) plasma membrane (Cnr1, Gnaz) signal transducer activity (Cnr1, Gnaz)
cytosol (Gnaz) aging (Cnr1) GTPase activity (Gnaz)
Cnr1 (Mus musculus)
Gnaz (Mus musculus)
Pain Link Frequency Relevance Heat
Endocannabinoid 6 98.32 Very High Very High Very High
Cannabinoid 162 95.88 Very High Very High Very High
Spinal cord 9 93.04 High High
Rostral ventromedial medulla 12 92.16 High High
Central grey 6 90.24 High High
Pain 9 88.48 High High
Analgesic 180 87.84 High High
Hippocampus 9 85.60 High High
amygdala 3 85.08 High High
cerebral cortex 3 84.68 Quite High
Disease Link Frequency Relevance Heat
Bordatella Infection 12 100.00 Very High Very High Very High
Nociception 9 98.64 Very High Very High Very High
Cognitive Disorder 3 97.24 Very High Very High Very High
Urological Neuroanatomy 30 90.72 High High
Pain 9 88.48 High High
Adhesions 3 84.80 Quite High
Hypothermia 3 27.68 Quite Low
Targeted Disruption 3 5.00 Very Low Very Low Very Low
Decapitation 3 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
There is compelling evidence that the CB1R couples to and regulates both PTX-sensitive Gi/o proteins and PTX-insensitive Gq/11 and Gz proteins.
CB1R Binding (couples) of Gz
1) Confidence 0.18 Published 2009 Journal Mol Pain Section Body Doc Link PMC2657119 Disease Relevance 0.05 Pain Relevance 0.66
At the molecular level, CB1R couples to pertussis toxin (PTX)-sensitive Gi/o proteins [14,15] and to certain pertussis toxin-insensitive G proteins, probably Gq/11 and Gz [16,17].
CB1R Binding (couples) of Gz associated with bordatella infection
2) Confidence 0.16 Published 2009 Journal Mol Pain Section Body Doc Link PMC2657119 Disease Relevance 0.83 Pain Relevance 1.12
At the molecular level, CB1R couples to pertussis toxin (PTX)-sensitive Gi/o proteins [14,15] and to certain pertussis toxin-insensitive G proteins, probably Gq/11 and Gz [16,17].
CB1R Binding (couples) of Gz associated with bordatella infection
3) Confidence 0.16 Published 2009 Journal Mol Pain Section Body Doc Link PMC2657119 Disease Relevance 0.83 Pain Relevance 1.12

General Comments

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