INT264930

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Context Info
Confidence 0.20
First Reported 2009
Last Reported 2009
Negated 0
Speculated 0
Reported most in Title
Documents 1
Total Number 1
Disease Relevance 0
Pain Relevance 1.14

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

signal transduction (Gnaz, Cnr1) plasma membrane (Gnaz, Cnr1) signal transducer activity (Gnaz, Cnr1)
cytosol (Gnaz) aging (Cnr1) GTPase activity (Gnaz)
Anatomy Link Frequency
brain 2
Gnaz (Mus musculus)
Cnr1 (Mus musculus)
Pain Link Frequency Relevance Heat
tolerance 49 98.48 Very High Very High Very High
Morphine 45 97.88 Very High Very High Very High
Cannabinoid 54 95.44 Very High Very High Very High
antinociception 10 94.56 High High
Analgesic 60 92.80 High High
cannabis 1 75.28 Quite High
analgesia 22 71.12 Quite High
Intracerebroventricular 1 61.76 Quite High
Cannabinoid receptor 3 59.84 Quite High
agonist 59 59.00 Quite High
Disease Link Frequency Relevance Heat
Bordatella Infection 4 32.56 Quite Low
Urological Neuroanatomy 10 5.00 Very Low Very Low Very Low
Pain 3 5.00 Very Low Very Low Very Low
Nociception 3 5.00 Very Low Very Low Very Low
Targeted Disruption 1 5.00 Very Low Very Low Very Low
Adhesions 1 5.00 Very Low Very Low Very Low
Cognitive Disorder 1 5.00 Very Low Very Low Very Low
Decapitation 1 5.00 Very Low Very Low Very Low
Hypothermia 1 5.00 Very Low Very Low Very Low

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
Gz mediates the long-lasting desensitization of brain CB1 receptors and is essential for cross-tolerance with morphine

Background

Gz Positive_regulation (mediates) of Negative_regulation (desensitization) of CB1 in brain associated with tolerance and morphine
1) Confidence 0.20 Published 2009 Journal Mol Pain Section Title Doc Link PMC2657119 Disease Relevance 0 Pain Relevance 1.14

General Comments

This test has worked.

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