INT264967

From wiki-pain
Jump to: navigation, search
Context Info
Confidence 0.18
First Reported 2007
Last Reported 2010
Negated 0
Speculated 0
Reported most in Body
Documents 4
Total Number 4
Disease Relevance 1.97
Pain Relevance 2.13

This is a graph with borders and nodes. Maybe there is an Imagemap used so the nodes may be linking to some Pages.

cell differentiation (PIK3CD) signal transduction (PIK3CD) plasma membrane (PIK3CD)
Anatomy Link Frequency
T cell 2
PIK3CD (Homo sapiens)
Pain Link Frequency Relevance Heat
Opioid 134 97.44 Very High Very High Very High
Inflammation 103 94.72 High High
Enkephalin 80 92.96 High High
Pain 56 92.72 High High
Endogenous opioid 4 91.80 High High
IPN 38 84.64 Quite High
Hyperalgesia 10 80.40 Quite High
Pain threshold 2 69.28 Quite High
antagonist 30 64.16 Quite High
cytokine 33 53.28 Quite High
Disease Link Frequency Relevance Heat
INFLAMMATION 109 94.72 High High
Pain 58 92.72 High High
Cancer 28 88.72 High High
Necrosis 5 88.24 High High
Inflammatory Pain 38 84.64 Quite High
Hyperalgesia 12 80.40 Quite High
Nociception 48 77.28 Quite High
Apoptosis 40 68.64 Quite High
Death 17 68.20 Quite High
Aging 103 54.40 Quite High

Sentences Mentioned In

Key: Protein Mutation Event Anatomy Negation Speculation Pain term Disease term
This requires activation of FPR as well as intracellular Ca2+ mobilization and PI3K activation, while TLR-2 and -4 do not seem to be involved.
Positive_regulation (requires) of Positive_regulation (activation) of PI3K
1) Confidence 0.18 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2657213 Disease Relevance 1.41 Pain Relevance 1.13
Interestingly, activation of PI3K can also increase RhoA activation [68].
Positive_regulation (increase) of Positive_regulation (activation) of PI3K
2) Confidence 0.16 Published 2010 Journal PLoS ONE Section Body Doc Link PMC2909203 Disease Relevance 0 Pain Relevance 0
In addition, activation via CD28 is very important for re-expression of the TCR, for the recruitment and stabilization of T cell lipid rafts to the “immunological synapse” and for the stimulation of the phosphoinositide kinase-3 (PI3K) signaling pathway (Tavano et al 2004).
Positive_regulation (important) of Positive_regulation (stimulation) of phosphoinositide kinase-3 in T cell
3) Confidence 0.14 Published 2007 Journal Clinical Interventions in Aging Section Body Doc Link PMC2684090 Disease Relevance 0.49 Pain Relevance 0.03
FPR is known to signal through Gi proteins stimulating phospholipase C leading to mobilization of Ca2+ from intracellular stores and to activation of PI3K [24].
Positive_regulation (leading) of Positive_regulation (activation) of PI3K
4) Confidence 0.12 Published 2009 Journal PLoS Pathogens Section Body Doc Link PMC2657213 Disease Relevance 0.07 Pain Relevance 0.98

General Comments

This test has worked.

Personal tools
Namespaces

Variants
Actions
Navigation
Toolbox